Medicinal Chemistry Research

, Volume 21, Issue 7, pp 1439–1444 | Cite as

Effect of complexation of 3-aminoquinoxaline-2-carbonitrile 1,4-dioxides with palladium and copper on their anti-T. cruzi activity

  • Diego Benítez
  • María L. Lavaggi
  • Dinorah Gambino
  • María H. Torre
  • Hugo Cerecetto
  • Mercedes González
Original Research
First Online:
Received:
Accepted:

Abstract

Pd(II) and Cu(II) complexes of 3-aminoquinoxaline-2-carbonitrile 1,4-dioxides were prepared in order to improve the anti-Trypanosoma cruzi activity of these ligands. The in vitro evaluations demonstrated that the metal complexation modified the activity of the ligands in different manners. Except for one compound, complexation with palladium increased the trypanosomicidal activity 20–80-times. Besides, copper also modified favorably the activity, however, the copper compounds resulted less active than the palladium ones, at the studied doses.

Keywords

Palladium complexes Copper complexes Chagas disease 3-Aminoquinoxaline-2-carbonitrile 1 4-dioxide Trypanosoma cruzi 
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Notes

Acknowledgments

DB wishes to thank ANII for scholarships. Financial support from RIDIMEDCHAG-CYTED is acknowledged.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Diego Benítez
    • 1
  • María L. Lavaggi
    • 1
  • Dinorah Gambino
    • 2
  • María H. Torre
    • 2
  • Hugo Cerecetto
    • 1
  • Mercedes González
    • 1
  1. 1.Laboratorio de Química OrgánicaFacultad de Ciencias-Facultad de Química, Universidad de la RepúblicaMontevideoUruguay
  2. 2.Department of Inorganic ChemistryFacultad de Química, Universidad de la RepúblicaMontevideoUruguay

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