Medicinal Chemistry Research

, Volume 21, Issue 7, pp 1283–1289 | Cite as

Antimycobacterial activity of fractions and isolated compounds from Vetiveria zizanioides

  • Shikha Gupta
  • Gaurav R. Dwivedi
  • Mahendra P. Darokar
  • Santosh K. Srivastava
Original Research

Abstract

The essential oil of Vetiveria zizanioides showed significant antimycobacterial activity against the drug-resistant strains of Mycobacterium smegmatis, which on activity guided fractionation afforded four bioactive fractions Vz-2, Vz-7, Vz-8, and Vz-9. Further purification of these bioactive fractions over preparative thin layer chromatographic resulted in the characterization of six compounds: 5, 10-pentadecadiyn-1-ol (1), α-curcumene (3), hydroxy junipene (4), (+) cycloisosativene (5), valencine (6), and selino 3,7 (11)-diene (7). All these compounds showed significant antimycobacterial activity against the drug-resistant strains (MDR-R and MDR-40) of M. smegmatis and their MIC was in the range of 31.25–62.5 μg/ml. These results may be of great help in antimycobacterial drug development from a very common, inexpensive, and non toxic natural product.

Keywords

Vetiveria zizanioides Mycobacterium smegmatis Drug-resistant strain Antimycobacterial activity 5,10-Pentadecadiyn-1-ol α-Curcumene Hydroxy junipene 

Notes

Acknowledgments

Financial support for this research by the Council of Scientific & Industrial Research (CSIR) is gratefully acknowledged. We also thank all of our colleagues for their excellent assistance.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Shikha Gupta
    • 1
  • Gaurav R. Dwivedi
    • 2
  • Mahendra P. Darokar
    • 2
  • Santosh K. Srivastava
    • 1
  1. 1.Analytical Chemistry DivisionCentral Institute of Medicinal and Aromatic Plants, P.O. CIMAPLucknowIndia
  2. 2.Molecular Bioprospection DepartmentCentral Institute of Medicinal and Aromatic Plants, P.O. CIMAPLucknowIndia

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