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Medicinal Chemistry Research

, Volume 21, Issue 7, pp 1127–1135 | Cite as

Dimeric 2-(2-chlorophenyl)-quinazolin-4-ones as potential antimicrobial agents

  • N. C. DesaiEmail author
  • Amit Dodiya
  • Nayan Bhatt
  • Mukesh Kumar
Original Research

Abstract

3-(Aryl)-2-(2-chlorophenyl)-6-{2-[2-(2-chlorophenyl)-4-oxo(3-hydroquinazolin-3yl)]ethyl}-3-hydroquinazolin-4-ones had been selected as target bio-active molecules. Several quinazoline derivatives were prepared by using anthranilic acid, acid chloride, 2-amino-ethanol, and different amines. Newly synthesized compounds were screened for their antibacterial and antifungal activities on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogenes, Candida albicans, Aspergillus niger, and Aspergillus clavatus. The compounds 5e, 5g, and 5h are shown to have excellent activity, while 5c, 5d, 5i, 5k, 5l are shown to have very good activity against several strains of bacteria. The structures of the synthesized compounds were firmly established by well-defined spectral analysis techniques like IR, 1H-NMR, 13C-NMR, and Mass spectra.

Keywords

Quinazolinone Antimicrobial activity of quinazolinone moiety Dimeric quinazolinone 

Notes

Acknowledgments

The authors express their sincere thanks to the Department of Chemistry and to Bhavnagar University, Bhavnagar for providing research facilities.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • N. C. Desai
    • 1
    Email author
  • Amit Dodiya
    • 1
  • Nayan Bhatt
    • 1
  • Mukesh Kumar
    • 1
  1. 1.Medicinal Chemistry Division, Department of ChemistryBhavnagar UniversityBhavnagarIndia

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