Medicinal Chemistry Research

, Volume 21, Issue 6, pp 796–803 | Cite as

Synthesis and antibacterial evaluation of Cu(II) and Zn(II) complexes of the β-lactum antibiotic, cefdinir

  • Deepika Sharma
  • Pradeep Kumar
  • Balasubramanian Narasimhan
Original Research
First Online:
Received:
Accepted:

Abstract

In this study, the coordination chemistry of the antibiotic, cefdinir, and its metal complexes with Cu (II) and Zn (II) was described and characterized on the basis of analytical and spectral studies. The synthesized complexes were evaluated in vitro for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli. The metal complexes possessed the better antibacterial activity against the selected species of bacteria than the free antibiotic (cefdinir). The results were supported by the increase in log P values of metal complexes in comparison to the free ligand cefdinir. The importance of these findings lies in the fact that these complexes could be applied in the treatment of common bacterial infections.

Keywords

Cefdinir Copper complex Zinc complex Antibacterial activity 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Deepika Sharma
    • 1
  • Pradeep Kumar
    • 2
  • Balasubramanian Narasimhan
    • 2
  1. 1.University Institute of Pharmaceutical SciencesPanjab UniversityChandigarhIndia
  2. 2.Faculty of Pharmaceutical SciencesMaharshi Dayanand UniversityRohtakIndia

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