Efficient synthesis of antihistamines clocinizine and chlorcyclizine
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A simple and efficient route has been developed for the synthesis of anti-histamine drugs clocinizine and chlorcyclizine. The common intermediate 1-[(4-chloro phenyl) (phenyl)-methyl]-piperazine (8), is prepared from (4-chlorophenyl) (phenyl)-methanone (5), in three steps with excellent yields. All the reactions proceeded smoothly and the products were also isolated easily.
KeywordsReduction Chlorination Clocinizine Chlorcyclizine Piperazine
One of the authors, PN is thankful to CSIR-New Delhi for providing with fellowship.
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