Medicinal Chemistry Research

, Volume 21, Issue 4, pp 538–541 | Cite as

Efficient synthesis of antihistamines clocinizine and chlorcyclizine

  • A. Venkat NarsaiahEmail author
  • P. Narsimha
Original Research


A simple and efficient route has been developed for the synthesis of anti-histamine drugs clocinizine and chlorcyclizine. The common intermediate 1-[(4-chloro phenyl) (phenyl)-methyl]-piperazine (8), is prepared from (4-chlorophenyl) (phenyl)-methanone (5), in three steps with excellent yields. All the reactions proceeded smoothly and the products were also isolated easily.


Reduction Chlorination Clocinizine Chlorcyclizine Piperazine 



One of the authors, PN is thankful to CSIR-New Delhi for providing with fellowship.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Organic Chemistry DivisionIndian Institute of Chemical TechnologyHyderabadIndia

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