Medicinal Chemistry Research

, Volume 20, Issue 7, pp 1068–1073 | Cite as

Synthesis of novel porphyrin-based lipids and their antibacterial activity

  • Amarnath Velidandi
  • Kranthi Kumar Gadidasu
  • V. Srilakshmi Patri
Original Research
First Online:
Received:
Accepted:

Abstract

The purpose of this study was to investigate the antibacterial activity of newly developed cationic amphiphilic lipids having porphyrin as head group against two types of gram-positive bacteria and three types of gram-negative bacteria. The antibacterial activity of quantitatively prepared porphyrin-based amphiphilic lipids is evaluated by the disc-diffusion method against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris. These results are compared with the standard antibacterial activity of chloramphenicol. Both lipids showed antibacterial behaviour against gram-positive and gram-negative bacteria.

Keywords

Porphyrin Cationic lipid Antibiotic Antibacterial activity 

Abbreviations

DCM

Dichloromethane

DDQ

2,3-Dichloro-5,6-dicyano-1,4-benzoquinone

ROS

Reactive oxygen species

S.A

Staphylococcus aureus

E.C

Escherichia coli

P.V

Proteus vulgaris

K.P

Klebsiella pneumoniae

B.S

Bacillus subtilis

MPs

Metalloporphyrins

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Notes

Acknowledgment

Financial supports for this work from Council of Scientific and Industrial Research, CSIR (to P. V. Srilakshmi.), Government of India, New Delhi (the doctoral research fellowship to V. Amarnath) is gratefully acknowledged. We sincerely acknowledge the experimental assistance for the studies of antibacterial activity received from G. Kranthi Kumar.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Amarnath Velidandi
    • 1
  • Kranthi Kumar Gadidasu
    • 2
  • V. Srilakshmi Patri
    • 1
  1. 1.Department of ChemistryNational Institute of Technology WarangalWarangalIndia
  2. 2.Department of BiotechnologyKakatiya UniversityWarangalIndia

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