Medicinal Chemistry Research

, Volume 20, Issue 9, pp 1509–1514 | Cite as

PASS-assisted exploration of new therapeutic potential of natural products

  • Rajesh Kumar Goel
  • Damanpreet Singh
  • Alexey Lagunin
  • Vladimir Poroikov
Original Research

Abstract

The use of drug substances derived from plants, fungi, bacteria, and marine organisms are “Mother Nature Gift” for diseases of mankind. Many of these are discovered serendipitously and have a long tradition in medicine. Till date, the use of natural products, their semisynthetic and synthetic derivatives have been mostly confined to their ethnic use. But it has been well known that each substance has a wide spectrum of biological activities as evident from some new uses of many old drugs. PASS (Prediction of Activity Spectra for Substances) has been employed as a strong potential tool to predict the biological activity spectrum of synthetic substances for the discovery of new drugs. But the potential of PASS to predict the biological activity spectra of natural products is still underestimated. The present study was therefore undertaken to investigate and correlate the biological activity spectrum of the main phytoconstituent of some selected Indian medicinal plants with their reported biological activities in order to evaluate the applicability of PASS. Further, the unexplored but PASS-predicted activities having good activity score (Pa > 0.7) for particular structure were listed as hidden potential of the plant.

Keywords

Ayurveda Biological activity spectrum Herbal drugs Natural products PASS 

Supplementary material

44_2010_9398_MOESM1_ESM.doc (112 kb)
Supplementary material 1 (DOC 112 kb)

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Rajesh Kumar Goel
    • 1
  • Damanpreet Singh
    • 1
  • Alexey Lagunin
    • 2
  • Vladimir Poroikov
    • 2
  1. 1.Department of Pharmaceutical Sciences and Drug ResearchPunjabi UniversityPatialaIndia
  2. 2.Institute of Biomedical Chemistry of Russian Academy of Medical SciencesMoscowRussia

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