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Medicinal Chemistry Research

, Volume 20, Issue 6, pp 726–731 | Cite as

Cytotoxic effect of a polymer–copper(II) complex containing 2,2′-bipyridyl ligand on human lung cancer cells

  • R. Senthil Kumar
  • V. S. Periasamy
  • C. Preethy Paul
  • A. Riyasdeen
  • S. ArunachalamEmail author
  • M. A. Akbarsha
Original Research

Abstract

The cytotoxic activity of the polymer–copper(II) complex, [Cu(bpy)2(BPEI)]Cl2·4H2O (bpy = 2,2′-bipyridine, BPEI = branched polyethyleneimine) on NCI-H460 human lung cancer cells was determined adopting MTT assay and specific staining techniques. Many of the cultured NCI-H460 cancer cells treated with this complex suffered loss of viability and death mostly through apoptosis and/or necrosis as evidenced by the changes in the nuclear morphology and cytoplasmic features.

Keywords

Polymer–metal complex Copper complex Cytotoxicity Apoptosis Necrosis 

Notes

Acknowledgements

The DST-FIST and UGC-SAP support for improvement of infrastructure facility at Animal Science Department of Bharathidasan University, and the UGC-SAP, COSIST, and DST-FIST programmes offered to the School of Chemistry are gratefully acknowledged.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • R. Senthil Kumar
    • 1
  • V. S. Periasamy
    • 2
  • C. Preethy Paul
    • 2
  • A. Riyasdeen
    • 2
  • S. Arunachalam
    • 3
    Email author
  • M. A. Akbarsha
    • 2
  1. 1.Laboratory of PhotomedicineEcole Polytechnique Fédérale de Lausanne (EPFL)LausanneSwitzerland
  2. 2.Department of Animal ScienceBharathidasan UniversityTiruchirappalliIndia
  3. 3.Department of ChemistryBharathidasan UniversityTiruchirappalliIndia

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