Medicinal Chemistry Research

, Volume 20, Issue 1, pp 125–129 | Cite as

2-Substituted-8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine as an anti-inflammatory agent

  • Ashish Kumar Tewari
  • Rashmi Dubey
  • Anil Mishra
Original Research


A series of 8-methyl-2-substituted-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine compounds have been synthesized in the present investigation utilizing Philips condensation (Philips, J Chem Soc 2393–2399, 1928). The anti-inflammatory activity of the synthesized compounds was evaluated using a carrageenin rat model.


8-Methyl-2-substituted-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine Anti-inflammatory Philips condensation 



The authors acknowledge the help of RSCI, CDRI Lucknow for providing the spectral analysis. Financial assistance from UGC India grant no F.31-139/2005 (SR), India is also gratefully acknowledged.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ashish Kumar Tewari
    • 1
  • Rashmi Dubey
    • 2
  • Anil Mishra
    • 2
  1. 1.Department of Chemistry, Faculty of ScienceBanaras Hindu UniversityVaranasiIndia
  2. 2.Department of ChemistryLucknow UniversityLucknowIndia

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