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Design and synthesis of 3-[3-(substituted phenyl)-4-piperidin-1-ylmethyl/-4-morpholin-4-ylmethyl-4,5-dihydro-isoxazol-5-yl]-1H-indoles as potent anti-inflammatory agents

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Abstract

The synthesis of new indole derivatives bearing isoxazoline moiety (3a–d and 4a–d) has been described. IR, 1H NMR, and mass spectral data supported the structures of synthesized compounds. The compounds were tested in vivo for their anti-inflammatory activity by carrageenin-induced rat paw edema method. The compounds that showed good anti-inflammatory activity were screened for their ulcerogenic and lipid peroxidation activities. The most active compound of this series is 3-[3-(4-methoxyphenyl)- 4-morpholin-4-ylmethyl)-4,5-dihydro-isoxazol-5yl]-1H-indole 4d.

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Acknowledgements

Sadique Akhtar Javed is grateful to the University Grant Commission-New Delhi, India, for financial assistance. The authors thank Mrs. Shaukat Shah, in-charge animal house, and Jamia Hamdard for providing Wistar rats.

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  1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi, 110 062, India

    Mohammad Amir, Sadique Akhtar Javed & Harish Kumar

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  1. Mohammad Amir
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  2. Sadique Akhtar Javed
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  3. Harish Kumar
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Correspondence to Mohammad Amir.

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Amir, M., Javed, S.A. & Kumar, H. Design and synthesis of 3-[3-(substituted phenyl)-4-piperidin-1-ylmethyl/-4-morpholin-4-ylmethyl-4,5-dihydro-isoxazol-5-yl]-1H-indoles as potent anti-inflammatory agents. Med Chem Res 19, 299–310 (2010). https://doi.org/10.1007/s00044-009-9194-8

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