Medicinal Chemistry Research

, Volume 19, Issue 4, pp 337–343 | Cite as

Cytotoxic lipid esters from Peucedanum ledebourielloides

  • Xing Zheng
  • Jiang Du
  • Yunlong Xu
  • Duanfang Liao
  • George R. Pettit
Original Research
First Online:
Received:
Accepted:

Abstract

Two cancer cell growth inhibitory esters, 1,2-dipalmitoyl-3-glucosyl glycerol (1) and 1,6-dihydroxy-hexane-bis-palmitoyl ester (2), together with arachidic acid-2-hydroxy-glycerol ester, daucosterol, and oleanolic acid, were isolated from the roots of Peucedanum ledebourielloides (Apiaceae family). The structures were determined by spectroscopic analyses. The esters 1 and 2 displayed significant activity against the SGC-7901, HT-29, and HL-60 cancer cell lines.

Keywords

Apiaceae family Peucedanum ledebourielloides Ester Anticancer 
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Notes

Acknowledgement

The authors thank the Department of Education of Hunan (07B065) and the Department Science and Technology of Hunan (2007FJ4155) for financial support. Special thanks are due to the Analytical Center, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany of Chinese Academy of Sciences, for recording IR, MS, and NMR spectra. The authors also thank Prof. Langran Xu for plant identification. Two authors (GRP and JD) are pleased to acknowledge the financial support of CA90441-5 and CA90441-06A1 awarded by the Division of Cancer Treatment and Diagnosis, National Cancer Institute, DHHS, the Arizona Biomedical Research Commission, and the assistance of Professor Fiona Hogan.

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Copyright information

© Birkhäuser Boston 2009

Authors and Affiliations

  • Xing Zheng
    • 1
    • 2
  • Jiang Du
    • 3
  • Yunlong Xu
    • 4
  • Duanfang Liao
    • 1
  • George R. Pettit
    • 2
  1. 1.Institute of Pharmacy and PharmacologyNanhua UniversityHengyangPeople’s Republic of China
  2. 2.Department of Chemistry and BiochemistryArizona State UniversityTempeUSA
  3. 3.Department of ChemistryColorado State UniversityFort CollinsUSA
  4. 4.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of BotanyChinese Academy of SciencesKunmingPeople’s Republic of China

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