Medicinal Chemistry Research

, Volume 19, Issue 3, pp 211–219 | Cite as

Three-dimensional common-feature hypotheses for hypoglycemic flavonyl-2,4-thiazolidinedione derivatives

  • Ilkay YildizEmail author
  • Oya Bozdag-Dundar
Original Research


Three-dimensional pharmacophore hypotheses were built from a set of seven antidiabetic agents. Among the ten commonly featured models generated by program Catalyst/HipHop, a hypothesis including four hydrogen-bond acceptors (HBAs) and two hydrophobic aromatics (HpArs) features was considered to be important in evaluating the hypoglycemic activity. The most active 3-ethyl-5-[3′-(4H-4-oxo-1-benzopyran-2-yl)benzylidene]-2,4-thiazolidinedione (4b) mapped well onto all the HBAs and HpArs features of the hypothesis.


Pharmacophore analysis HipHop Hypoglycemic agents 2,4-thiazolidinediones 2,4-imidazolidinediones 2-thiohydantoin Flavone 


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Copyright information

© Birkhäuser Boston 2009

Authors and Affiliations

  1. 1.Faculty of Pharmacy, Department of Pharmaceutical ChemistryAnkara UniversityAnkaraTurkey

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