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Medicinal Chemistry Research

, Volume 17, Issue 8, pp 507–514 | Cite as

Synthesis and pharmacological evaluation of 4-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

  • Jerzy KossakowskiEmail author
  • Anna Bielenica
  • Marta Struga
  • Anna E. Koziol
Original Research

Abstract

The synthesis and pharmacological activity of 4-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione is described. The structure of the compound was confirmed by elemental analysis, 1H nuclear magnetic resonance (NMR), 13C NMR, mass spectra, and X-ray crystallography. The compound exhibited significant affinity to both 5-HT1A and 5-HT2A receptors, similarly to aripiprazole, which is an atypical antipsychotic drug.

Keywords

Cyclic imide derivative N-phenylpiperazine derivative 5HT1A and 5HT2A receptor affinity 

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Copyright information

© Birkhäuser Boston 2008

Authors and Affiliations

  • Jerzy Kossakowski
    • 1
    Email author
  • Anna Bielenica
    • 1
  • Marta Struga
    • 1
  • Anna E. Koziol
    • 2
  1. 1.Department of Medical ChemistryThe Medical University of WarsawWarsawPoland
  2. 2.Faculty of ChemistryMaria Curie-Sklodowska UniversityLublinPoland

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