Medicinal Chemistry Research

, Volume 16, Issue 7–9, pp 342–351 | Cite as

QSAR study on some arylsulfonamides as anti-HIV agents

  • Veerasamy Ravichandran
  • Prateek Kumar Jain
  • Vishnu Kant Mourya
  • Ram Kishore Agrawal
Original Research
First Online:
Received:
Accepted:

Abstract

In pursuit of better anti-HIV drugs, quantitative structure-activity relationship (QSAR) studies were performed on a series of aryl sulfonamide HIV protease inhibitors using Win CAChe 6.1. Multiple linear regression analysis was performed to derive QSAR models, which were further evaluated for statistical significance and predictive power by internal and external validation. The QSAR model indicates that the thermodynamic descriptors (heat of formation, log P, and molar refractivity) and steric descriptor (solvent assessable surface area) play an important role for the anti-HIV activity. The results of the present study may be useful on the designing of more potent anti-HIV agents.

Keywords

QSAR Arylsulfonamides HIV-1 protease inhibitors Anti-HIV agents 
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Notes

Acknowledgments

One of the authors (VR) is thankful to AICTE, New Delhi for providing a (QIP) fellowship and the authors would like to thank Mr. Nowley of the Government College of Pharmacy, Auranagabad, India for his valuable help.

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Copyright information

© Birkha¨user Boston 2007

Authors and Affiliations

  • Veerasamy Ravichandran
    • 1
  • Prateek Kumar Jain
    • 1
  • Vishnu Kant Mourya
    • 2
  • Ram Kishore Agrawal
    • 1
    • 3
  1. 1.Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical SciencesDr. H. S. Gour VishwavidyalayaSagarIndia
  2. 2.Govt. College of PharmacyAurangabadIndia
  3. 3.Pharmaceutical Chemistry Research Laboratory, Dept. of Pharmaceutical SciencesDr. H. S. Gour UniversitySagarIndia

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