International Journal of Public Health

, Volume 63, Issue 7, pp 833–845 | Cite as

Occupational prestige trajectory and the risk of lung and head and neck cancer among men and women in France

  • Gwenn MenvielleEmail author
  • Julien Dugas
  • Jeanna-eve Franck
  • Matthieu Carton
  • Brigitte Trétarre
  • Isabelle Stücker
  • Danièle Luce
  • Icare group
Original Article



This study aimed at investigating the associations between occupational prestige trajectories and lung and head and neck (HN) cancer risk and to assess to what extent smoking, alcohol drinking, and occupational exposures contribute to these associations.


Using data from the ICARE case–control study (controls (2676 men/715 women), lung cancers (2019 men/558 women), HN cancers (1793 men/305 women), we defined occupational prestige trajectories using group-based modeling of longitudinal data. We conducted logistic regression models.


Among men, a gradient was observed from the downward “low to very low” trajectory to the stable very high trajectory. The associations were reduced when adjusting for tobacco and alcohol consumption and occupational exposures. Among women, when compared to the stable high trajectory, there was an increased cancer risk in all trajectories. The associations remained globally unchanged or even increased after adjustment for tobacco and alcohol consumption and did not change when adjusting for occupational exposures. The ORs were smaller for lung than for HN cancers in men.


Occupational prestige trajectory is strongly associated with lung and HN cancer risk in men and women.


Occupational prestige trajectory Alcohol Smoking Occupational exposures Respiratory cancer 


Members of Icare Study Group

Registre des cancers du Calvados, France (Anne-Valérie Guizard); Registre des cancers du Doubs, France (Arlette Danzon, Anne-Sophie Woronoff); Registre des cancers du Bas-Rhin, France (Michel Velten); Registre des cancers du Haut-Rhin, France (Antoine Buemi, Émilie Marrer); Registre des cancers de l’Hérault, France (Brigitte Tretarre); Registre des cancers de l’Isère, France (Marc Colonna, Patricia Delafosse); Registre des cancers de Loire-Atlantique-Vendée, France (Paolo Bercelli, Florence Molinie); Registre des cancers de la Manche, France (Simona Bara); Registre des cancers de la Somme, France (Benedicte Lapotre-Ledoux, Nicole Raverdy); Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of cancer Team, Villejuif, France (Sylvie Cénée, Oumar Gaye, Florence Guida, Farida Lamkarkach, Loredana Radoï, Marie Sanchez, Isabelle Stücker); Inserm Epidemiologic Cohorts Unit - UMS 011 INSERM-UVSQ, Villejuif, France (Matthieu Carton, Diane Cyr, Annie Schmaus). Unité Mixte de Recherche Épidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE), France (Joëlle Févotte, Corinne Pilorget). Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France (Gwenn Menvielle). Inserm U 1085—IRSET, Pointe-à-Pitre, France (Danièle Luce).


This work was supported by a grant from the French Agency for Food, Environmental and Occupational Health and Safety (ANSES) [grant number EST-2009/1/65]. The ICARE study was funded by French National Research Agency (ANR); French National Cancer Institute (INCA); French Agency for Food, Environmental and Occupational Health and Safety (ANSES); French Institute for Public Health Surveillance (InVS); Fondation pour la Recherche Médicale (FRM); Fondation de France; La Fondation ARC pour la Recherche sur le Cancer; Ministry of Labour (Direction Générale du Travail); and Ministry of Health (Direction Générale de la Santé).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all participants included in the study.


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Copyright information

© Swiss School of Public Health (SSPH+) 2017

Authors and Affiliations

  • Gwenn Menvielle
    • 1
    Email author
  • Julien Dugas
    • 2
    • 3
  • Jeanna-eve Franck
    • 1
  • Matthieu Carton
    • 4
  • Brigitte Trétarre
    • 5
  • Isabelle Stücker
    • 6
  • Danièle Luce
    • 2
    • 3
  • Icare group
  1. 1.INSERM, Institut Pierre Louis d’épidémiologie et de Santé Publique (IPLESP UMRS 1136)Sorbonne Universités, UPMC Univ Paris 06ParisFrance
  2. 2.INSERM, U 1085_IRSETPointe-À-PitreFrance
  3. 3.University of Rennes 1RennesFrance
  4. 4.Institut CuriePSL Research University, DRCIBiométriesaint-CloudFrance
  5. 5.Cancer Registry HéraultICM MontpellierMontpellierFrance
  6. 6.UVSQ, CESP, INSERM, Environmental Epidemiology of Cancer TeamUniversity Paris Sud, Paris Saclay UniversityVillejuifFrance

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