Harnessing advances in computer simulation to inform policy and planning to reduce alcohol-related harms
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Alcohol misuse is a complex systemic problem. The aim of this study was to explore the feasibility of using a transparent and participatory agent-based modelling approach to develop a robust decision support tool to test alcohol policy scenarios before they are implemented in the real world.
A consortium of Australia’s leading alcohol experts was engaged to collaboratively develop an agent-based model of alcohol consumption behaviour and related harms. As a case study, four policy scenarios were examined.
A 19.5 ± 2.5% reduction in acute alcohol-related harms was estimated with the implementation of a 3 a.m. licensed venue closing time plus 1 a.m. lockout; and a 9 ± 2.6% reduction in incidence was estimated with expansion of treatment services to reach 20% of heavy drinkers. Combining the two scenarios produced a 33.3 ± 2.7% reduction in the incidence of acute alcohol-related harms, suggesting a synergistic effect.
This study demonstrates the feasibility of participatory development of a contextually relevant computer simulation model of alcohol-related harms and highlights the value of the approach in identifying potential policy responses that best leverage limited resources.
KeywordsAgent-based modelling Alcohol-related harm Prevention policy Evidence synthesis
Alcohol misuse is a complex systemic problem. Globally, alcohol is estimated to result in 3.3 million deaths each year, with resultant health and social costs accounting for more than 1% of the gross national product of high- and middle-income countries (Rehm et al. 2009; World Health Organization 2014). Evidence suggests that alcohol misuse and related harms arise from a complex aetiology that includes a range of interacting individual, sociocultural, economic and environmental risk factors (International Center for Alcohol Policies 2009). A number of options are available for addressing the harms arising from alcohol misuse including pricing and taxation policies, regulating the availability of alcohol, modifying the alcohol consumption environment, drink-driving countermeasures, restrictions on marketing of alcohol products, education and persuasion, clinical treatment and early interventions (Babor et al. 2010; Martineau et al. 2013). Despite the availability of evidence regarding the effectiveness of such options, the selection of effective responses to this complex problem is challenged by a lack of clarity on how multi-level risk factors of alcohol misuse interact and change over time. There is also uncertainty regarding the impacts of interventions at the population level in particular contexts and the likely effects of combining them, which is further compounded by differing stakeholder priorities and views regarding the most appropriate approaches. Further, political considerations, community advocacy and industry lobbying can give rise to promulgation of, or resistance to, particular policy response options.
To better understand complexity and manage uncertainty, a range of sciences make use of computer simulation to estimate the impacts of certain actions (Winsberg 2010). Agent-based modelling is one type of computer simulation modelling approach that has been used in this way since the mid-1990s to understand social dynamics (Epstein and Axtell 1996). More recently, it has been applied to complex public health problems to help inform policy and practice (Nianogo and Arah 2015). Agent-based modelling involves the development of an artificial population of individuals (agents) with key characteristics of a real-world population and simple behavioural rules to define their activities and interactions within a given environment and with each other (Epstein and Axtell 1996). Agent interactions and introduction of changes or interventions to the environment result in emergent behaviours and outcomes at the population level, which are plotted over time. Unlike other forecast modelling, agent-based models explicitly represent the causal hypothesis underlying a complex problem, accounting for interdependencies of risk factors, changes over time, feedback loops (vicious and virtuous cycles) and real-world inertia and delay. Agent-based model development draws together into a single, coherent representation a variety of evidence sources such as conceptual models, research evidence and routine data. To establish the basic plausibility of the articulated hypothesis, and ensure the resulting model is a valid representation of the real-world system, model outputs are compared against real-world historic data patterns across a range of indicators. The final product is a ‘what-if’ tool that can simulate different scenarios to explore their likely impacts over the short and longer term, before they are implemented in the real world.
Recent advances in software capability and more user-friendly interfaces mean that agent-based modelling is now more accessible to non-modellers. The improvements in model transparency that these software advances afford facilitates meaningful critique of model structure, parameterisation and assumptions by stakeholders, and builds greater confidence in the results produced by the model (Atkinson et al. 2017; Hovmand et al. 2014). This has allowed stakeholder engagement and participatory approaches to be embedded into the development of sophisticated simulation tools, which may address some of the challenges of building consensus for effective, coordinated action to address alcohol-related harms (Atkinson et al. 2017; Haute Autorite de Sante 2010; Hovmand et al. 2014).
Several agent-based models of alcohol consumption behaviour have been developed. They capture elements of the social dynamics and environmental influences on alcohol consumption behaviours, neurobiological responses to alcohol use, the evolution of alcohol outlets and alcohol consumers in a community, and the acute harms that arise from heavy alcohol consumption among young people (Fitzpatrick and Martinez 2012; Gorman et al. 2006; Lamy et al. 2011; Scott et al. 2016). These models provide valuable insights into alcohol consumption behaviour and harms, but the range of harms explored by each model, and the range of interventions able to be tested, are limited by model scope. In addition, these models were developed by researchers in isolation from stakeholders and decision makers. The aim of this study was to explore the feasibility of a participatory agent-based modelling approach that provides decision makers and key stakeholders with a sophisticated and robust decision support tool to test the likely impacts of different policy scenarios before they are implemented in the real world.
The model development process drew on best practice guidelines for computational modelling and included grounding of assumptions in theory and evidence, sensitivity testing and calibration (Hammond 2015). The model was built using a participatory approach (Atkinson et al. 2017) that engaged a consortium of academics, policy experts, clinicians, programme planners and health economists in the process. A full description of the participatory approach and insights are provided elsewhere (Atkinson et al. 2017; Freebairn et al. 2017). The agent-based model was constructed using AnyLogic simulation software (http://www.anylogic.com/).
The purpose of the model was to inform the choice and design of policy responses to the problem of alcohol-related harms in New South Wales, Australia, through the testing of combinations of interventions. Interventions and harms included in the model are listed in Online Resource 1—Boxes 1 and 2.
The model included features of the alcohol consumption environment in NSW, consisting of licensed venues (bars, pubs, nightclubs) grouped to represent entertainment precincts of varying density where individuals can consume alcohol. The model also contained work places, bottle shops (retail outlets) where alcohol can be purchased and homes where alcohol can be consumed. Bottle shops, workplaces and homes were distributed randomly within the environment, using variation in average travel time as a replacement for distance to bottle shops and licensed venues to simplify geographic and routing concerns and as a proxy for urban/rural differences. Licensed venues in the model were grouped into precincts to represent alcohol consumption destinations. Individuals in the model consume alcohol at licensed venues (bars, pubs, nightclubs), peer events (parties) and home. Individuals can be refused entry to, or ejected from, licensed venues due to time of day (i.e. closing time), identified intoxication (i.e. refusal to serve alcohol due to responsible service of alcohol (RSA) requirements) and ‘lockouts’ (a policy whereby new patrons are no longer admitted to venues after a particular time of night). Peer events are periodically hosted by individuals at home and are attended by members of an individual’s friend network. In the model, alcohol can be obtained from bottle shops for consumption at home, peer events and for pre-loading purposes (the practice of consuming alcohol at a private residence before going to a place where alcohol access might be expensive, limited or prohibited).
Alcohol consumption behaviour
Consistent with the COM-B conceptual model of alcohol consumption behaviour in context (Fishbein et al. 2001; Michie et al. 2011), a set of rules was established to govern the likelihood that an individual in the model will consume alcohol. These rules were grouped using the COM-B framework (Online Resource 1—Box 3) under: ‘Capacity’ which defines whether the individual can consume alcohol in their current state; ‘Opportunity’ defines where they might consume alcohol; and ‘Motivation’ defines how much they will consume alcohol once there, which over time resulted in an emergent alcohol consumption pattern (‘Behaviour’) (Online Resource 1—Box 4).
Alcohol consumption episode and blood alcohol concentration (BAC)
The number of years spent consuming alcohol at a given level impacts risk of chronic harms.
Context affects acute harm generation. For example, road traffic accidents are only possible when an individual is in transit.
Demographics influence harm generation and outcomes. For example, males are more likely than females to engage in violence and are more likely to do so with other males; young adults are more likely to suffer acute harms than older adults.
Harms produce unequal health-care system burden. For example, violence/assaults rarely translate into hospitalisation; alcohol poisoning frequently results in emergency department (ED) presentations; acute expressions of severe chronic alcohol use disorder almost always produce hospitalisations.
Acute harms In the model, the risk of acute harms increases non-linearly with BAC, age, sex and context at any given point in time (see Online Resource 2 for risk estimates). Acute harms may be sufficiently severe to result in an ED presentation, hospitalisation or mortality. Acute harms represented in the model were reported as a mean per 100,000 population and include: unintentional injuries (e.g. drowning, falls, fires), alcohol poisoning, road traffic accidents, violence/assault (as a victim or perpetrator) and acute exacerbations resulting from chronic alcohol use disorder (e.g. pancreatitis, gastritis, bleeding and ulcers, mental/behavioural disturbances).
The attributable fraction for alcoholic liver cirrhosis is 1. Alcohol-related chronic harms, ED presentations, hospitalisations and mortality generated by the model were reported as a mean per 100,000 population (18 years and over) and plotted over time. For each acute and chronic harm generated, an individual’s ID number, age, sex, alcohol consumption category and type of harm were recorded, creating a synthetic longitudinal dataset of which questions can be asked and traditional statistical analyses conducted.
Mortality occurs in the model as a result of alcohol-related acute and chronic harms. In addition, background mortality rates unrelated to alcohol consumption occurred in the model based on age-related mortality curves for NSW (Australian Bureau of Statistics 2014). Upon death of an individual, they were removed from the model.
Data sources, time frame and calibration
Model assumptions and supporting citations are provided in Online Resource 1—Box 5. The structure and parameterisation of the model drew on a range of evidence and data sources, including systematic reviews (and meta-analyses), longitudinal studies, well-accepted formulas and conceptual models, local survey data and economic data (Online Resource 3). Model structure and parameterisation was reviewed and modified in response to the combined expert knowledge of participating stakeholders through a series of model co-design workshops to reach consensus (Atkinson et al. 2017). In addition, demographic data were sourced from the Australian Bureau of Statistics; drinking behaviour data sourced from the National Drug Strategy Household Survey (NSW and Australian data); and incidence of harm, ED presentations and hospitalisations data were sourced from the Australian Burden of Disease Study dataset and NSW Health administrative datasets. Parameter values, their sources and data used for model calibration are provided in Online Resource 2. The model was calibrated to approximate population statistics from 2011 to 2016 (for alcohol-related harm outputs of the model to be compared against real-world data of that period for validation) and then progresses from January 1, 2017 to December 31, 2021 when simulating interventions. Details regarding model calibration are provided in Online Resource 1—Box 6. The model broadly reproduced historic data patterns across a range of outcome indicators selected on advice from the expert stakeholder group Online Resource 1—Box 7. During the development process, model outputs were iteratively compared to real-world data to ensure that statistics were emerging not as artefacts but due to plausible causal mechanisms.
The baseline scenario (business as usual) used conditions in place across the majority of NSW as of 2016 (i.e. bottle shop closing time of 10 p.m., and licensed venue closing time of 5 a.m.). While the model can simulate a large range of possible combinations of interventions, the following intervention scenarios targeting the reduction of acute alcohol-related harms over the short term were selected as a case study to highlight the policy value of the tool:
Scenario 1: 3 a.m. closing time of licensed venues + 1 a.m. ‘lockouts’ rolled out across NSW in 2017.
Scenario 2: 3 a.m. closing time of licensed venues rolled out across NSW in 2017.
Scenario 3: Expansion of treatment services (to achieve 20% coverage of heavy drinkers) introduced in 2017.
Scenario 4: 3 a.m. closing time of licensed venues + 1 a.m. ‘lockouts’ rolled out across NSW + expansion of treatment services (20% coverage of heavy drinkers) introduced in 2017.
Key outcome indicators against which the impacts of scenarios were compared to the baseline were: (1) incidence of acute alcohol-related harms, (2) ED presentations and (3) hospitalisations. To account for stochasticity, each simulation was run 12 times. A description of the output data processing method is presented in Online Resource 4. Baseline summary statistics for key outcome indicators are presented as a monthly mean per 100,000 population across the 12 runs. In addition, comparison of simulation results between baseline and intervention scenarios was expressed as a percent difference in the mean of two independent samples from the same population.
Summary statistics for key outcomes generated from 12 runs of the baseline (NSW, Australian; simulated from 2017 to 2021)
Mean monthly harms generated (per 100,000 population)
SD % of mean
Margin of error
Incidence of acute harms
Emergency department presentations
Summary of reductions from the baseline for each scenario (NSW, Australia; simulated from 2017 to 2021)
Incidence of acute harms % reduction
Margin of error %
Emergency department presentation % reduction
Margin of error %
Hospitalisations % reduction
Margin of error %
Scenario 1 estimated a 19.5 ± 2.9% reduction in acute alcohol-related harms, an 18.5 ± 2.5% reduction in ED presentations and a 15.7 ± 2.1% reduction in hospitalisations between 2017 and the end of 2021.
Scenario 2 estimated a 12.3 ± 2.4% reduction in acute alcohol-related harms, an 11.9 ± 2.1% reduction in ED presentations and a 10.6 ± 1.8% reduction in hospitalisations between 2017 and the end of 2021.
Scenario 3 estimated a 9 ± 2.9% reduction in acute alcohol-related harms, a 10.8 ± 2.6% reduction in ED presentations and a 12.8 ± 2·3% reduction in hospitalisations between 2017 and the end of 2021.
Scenario 4 estimated a 33.3 ± 2.7% reduction in acute alcohol-related harms, a 36.6 ± 2.7% reduction in ED presentations and a 37.2 ± 2.6% reduction in hospitalisations between 2017 and the end of 2021.
In Australia, political considerations, community and public health advocacy, industry lobbying and a pro-drinking culture is contributing to a hotly contested debate about the most appropriate course of action to reduce alcohol-related harms (Atkinson et al. 2017; Howard et al. 2014). In addition, Commonwealth, state and territory governments have jurisdiction over different policy areas, resulting in a lack of coherent and coordinated responses to this complex problem (Howard et al. 2014). This work demonstrates the feasibility of participatory development of a contextually relevant agent-based model of alcohol-related harms and highlights its utility in identifying potential policy responses that best leverage limited resources: responses that would otherwise take many years to test and evaluate.
Complex problems such as alcohol misuse and related harms often require multi-strategic cross-agency responses. Commonly, interventions under the jurisdiction of a responding policy agency that are deemed likely to be effective are often packaged, refined based on stakeholder consultation and implemented without adequate understanding of their likely combined effect. In contrast, computer models allow the testing of alternative combinations of interventions and quantify the trade-offs between different combinations of interventions, providing a robust basis on which to negotiate effective and acceptable responses and help avoid a costly trial and error approach. The findings of this study show that scenario 1 (the 3 a.m. closing time of licensed venues + 1 a.m. ‘lockouts’) combined with scenario 3 (the expansion of treatment services to achieve 20% coverage of heavy drinkers) resulted in impacts that are greater than the sum of the scenarios simulated individually, indicating a synergistic effect. This is consistent with the non-additive effects noted as an important corollary of interventions in complex systems (Forrester 1961; Marshall et al. 2015; Rockhill et al. 1998). The potential synergistic effects of interventions delivered by different agencies (health, police, justice and welfare departments and other government, academic and community organisations) may assist in making a compelling case for cross-agency cooperation to deliver coordinated and effective responses to address alcohol misuse and related harms. While the work presented is a case study of the application of participatory agent-based modelling to inform policy and planning in New South Wales (NSW), Australia, the approach is applicable nationally and globally.
Model limitations and strengths The baseline model underestimates alcohol poisoning among young adults, but reasonably reproduces this poisoning in the adult population generally. This shortcoming skews the proportion of harms generated by problem groups (i.e. males, individuals under 40 years and individuals with alcohol use disorders), but will be refined in future versions. In addition, while the model initiates new alcohol consumption legal age individuals as time passes, it does not incorporate immigration/migration to or from NSW. This results in a total population reduction over time (~ 0.45%/year). Immigration/migration was not included for reasons of simplicity and lack of data, particularly around drinking category estimates of individuals moving to NSW. However, model outputs are reported as a mean per hundred thousand population, to account for variation in population size over time. In addition, the model does not include domestic violence; hence, total acute harms will be underestimated in both the baseline and simulated runs of the model. Finally, population-level evidence was often used to parameterise individual-level transitions in the agent-based model, due to a lack of more detailed individual-level data regarding the impact of interacting exposures on drinking behaviours. Further collection of individual behavioural trajectory data (using sensor-enabled wearable devices and mobile technologies) would make a valuable contribution to improving model robustness, particularly to improve model representation of the interactions between workplace drinking culture, gender-related social expectations around drinking in particular contexts and peer pressure related to an individual’s social network. However, the primary purpose of the model was to provide decision support capability by estimating the overall comparative impacts of different policy scenarios or combinations of interventions over time against the baseline, rather than providing highly precise predictions of outcome indicators. A strength of the study, and a key innovation in the application of agent-based modelling to complex public health problems, is the explicit engagement of diverse stakeholders in the design and parameterisation of the tool (Atkinson et al. 2015, 2017; Freebairn et al. 2017; O’Donnell et al. 2017). The participatory approach assisted in transparent negotiation and consensus building around the most acceptable policy options in the context of previous, and sometimes contentious, empirical evidence. This approach has developed an effective and acceptable cross-sectoral policy analysis tool to inform responses to reducing alcohol-related harms.
Ongoing utility as a decision support asset The NSW alcohol model can be used in an ongoing way as a decision support asset in NSW and may be customised for use in other jurisdictions within Australia or internationally. Models such as this act as a logically consistent framework for integrating disparate data and evidence sources to better understand and address complex problems. In addition, models can be iteratively updated to maintain their utility as a decision support asset and can be used to identify research priorities that will contribute to improving and refining the model and enhancing its value over time. It also allows policy makers to leverage further investment in research, big data collection and analysis, and evaluation of policies and programs. As new evidence comes to light and as new interventions are tested and evaluated, the results can be integrated into the model to help derive more quickly actionable policy and practice recommendations.
The authors would like to thank Professor Nate Osgood for his valuable contributions and advice during various stages of the planning and implementation and review of this work.
The alcohol modelling consortium: members of this group provided important intellectual contributions to the development and critique of the model through the participatory process as well as to manuscript preparation. The group comprised: Dr. Jo-An Atkinson (The Australian Prevention Partnership Centre (TAPPC), Sax Institute; University of Sydney), Dylan Knowles (Anthrodynamics Simulation Services), Professor John Wiggers (TAPPC; Hunter New England Local Health District; University of Newcastle), Professor Robin Room (Centre for Alcohol Policy Research, La Trobe University), Dr. Michael Livingston (Centre for Alcohol Policy Research, La Trobe University), Professor Kate Conigrave (University of Sydney; Royal Prince Alfred Hospital), Professor Chris Rissel (NSW Office of Preventive Health; University of Sydney), Philip Coates (NSW Treasury), Dr. David Muscatello (University of NSW), Professor Paul Haber (University of Sydney; Drug Health Services, Sydney Local Health District), Dr. Nghi Phung (Addiction Medicine, Westmead Hospital; Western Sydney Local Health District), Ralph Moore (South Eastern Sydney Local Health District), Associate Professor Leena Gupta (University of Sydney; Sydney Local Health District), Associate Professor Nadine Ezard (St Vincent’s Hospital), Fiona Renshaw (Murrumbidgee Local Health District), Professor Sandra Jones (Australian Catholic University), Karen Price (ACON), Dr. Jo Mitchell (NSW Ministry of Health), Genevieve Whitlam (NSW Ministry of Health), Nicola Lewis (NSW Ministry of Health), Dr. Ante Prodan (TAPPC, Sax Institute; Western Sydney University), Eloise O’Donnell (TAPPC), Dr. Geoff McDonnell (TAPPC, Sax Institute; Adaptive Care Systems), Mark Heffernan (Dynamic Operations), Louise Freebairn (TAPPC; ACT Health), Michael Lambert (Sax Institute), Jaithri Ananthapavan (Deakin University), Professor Lucie Rychetnik (TAPPC; University of Notre Dame), Professor Sally Redman (Sax Institute), Professor Alan Shiell (La Trobe University), Dr. Devon Indig (University of Sydney), Luke Penza (Western Sydney University), Associate Professor Sonia Wutzke (TAPPC, Sax Institute; University of Sydney) and Professor Andrew Wilson (TAPPC; University of Sydney).
All authors contributed to the conception of the paper. AP conducted data analysis. JA, DK and AP drafted the manuscript. All authors have made important intellectual contributions to model development and manuscript draft revisions. All authors have read and approved the final manuscript.
Compliance with ethical standards
Role of the funding source
This research was supported by the Australian Prevention Partnership Centre through the National Health and Medical Research Council (NHMRC) partnership centre grant scheme (Grant ID: GNT9100001) with the Australian Government Department of Health, NSW Ministry of Health, ACT Health, HCF and the HCF Research Foundation. The contents of this paper are solely the responsibility of the individual authors and do not reflect the views of the NHMRC or the funding partners.
Conflict of interest
JA (Ananthapavan) reports grants from the Australian Prevention Partnership Centre during the conduct of the study. ML reports grants from the National Health and Medical Research Council (NHMRC) during the conduct of this study. JA (Atkinson) and SW report grants from the NHMRC Partnership Centre grant scheme during the conduct of the study. DK reports income from Anthrodynamics Simulation Services Ltd. outside the contracted work during the conduct of the study. All other authors declare that they have no competing interests.
- Australian Bureau of Statistics (ABS) (2014) Deaths, Australia. http://www.abs.gov.au/AUSSTATS/abs@.nsf/DetailsPage/3302.02014?OpenDocument. Accessed 6 Jan 2017
- Begg S, Vos T, Barker B et al (2007) Burden of disease and injury in Australia, 2003. Cat. no. PHE 82. Australian Institute of Health and Welfare. http://www.aihw.gov.au/publications/index.cfm/title/10317, Canberra. Accessed 6 Jan 2017
- Epstein JM, Axtell RL (1996) Growing artificial societies: social science from the bottom up. The MIT Press, CambridgeGoogle Scholar
- Fishbein M, Kanfer F, Becker M, Middlestadt S, Eichler A (2001) Factors influencing behaviour and behaviour change. In: Baum A, Revenson T, Singer J (eds) Handbook of health psychology. Lawrence Erlbaum Associates, Mahwah, pp 3–17Google Scholar
- Forrester J (1961) Industrial dynamics. The M.I.T Press, CambridgeGoogle Scholar
- Hammond R (2015) Considerations and best practices in agent-based modeling to inform policy. In: Assessing the use of agent-based models for tobacco regulation. National Academies Press, Washington (DC). https://www.ncbi.nlm.nih.gov/books/NBK305917/. Accessed 6 Jan 2017
- Haute Autorite de Sante (2010) Practice guidelines: “Formal consensus” method. HAS, France. http://www.has-sante.fr/portail/upload/docs/application/pdf/2011-06/guideline_by_formal_consensus_quick_methodology_guide_110531.pdf. Accessed 6 Jan 2017
- Hovmand P, Osgood N, Alison Kraus et al (2014) Extending group model building to agent based modeling: a case study on understanding the paradox of primary care. In: Paper presented at the 32nd international conference of the system dynamics society. The Delft, the Netherlands. http://www.systemdynamics.org/conferences/2014/proceed/proceed.pdf. Accessed 6 Jan 2017
- International Center for Alcohol Policies (2009) Determinants of drinking. ICAP health issues (online). http://www.icap.org/linkclick.aspx?fileticket=oHFi97riJos%3d&tabid=243. Accessed 6 Jan 2017
- Lamy F, Perez P, Ritter A, Livingston M (2011) An agent-based model of alcohol use and abuse: SimARC. In: Paper presented at the proceedings of the 7th European social simulation association conference, Montpellier: ESSAGoogle Scholar
- Marsden Jacob Associates (2012) Bingeing, collateral damage and the benefits and costs of taxing alcohol rationally. Prepared for the Foundation for Alcohol Research and Education: http://fare.org.au/wp-content/uploads/research/FINAL-MJA-Report-Bingeing-Collateral-Damage-and-Taxation-2012.pdf. Accessed 6 Jan 2017
- Marshall DA, Burgos-Liz L, IJzerman MJ et al (2015) Applying dynamic simulation modeling methods in health care delivery research-the SIMULATE checklist: report of the ISPOR simulation modeling emerging good practices task force. Value Health 18:5–16. doi: 10.1016/j.jval.2014.12.001 CrossRefPubMedGoogle Scholar
- National Health and Medical Research Council (NHMRC) (2009) Australian Guidelines to reduce health risks from drinking alcohol. Australian Government, NHMRC, Canberra, Australia. https://www.nhmrc.gov.au/_files_nhmrc/publications/attachments/ds10-alcohol.pdf. Accessed 6 Jan 2017
- Widmark EMP (1981) Principles and applications of medicolegal alcohol determination. Biomedical Publications, DavisGoogle Scholar
- World Health Organization (2014) Global status report on alcohol and health. WHO, Luxembourg. http://apps.who.int/iris/bitstream/10665/112736/1/9789240692763_eng.pdf. Accessed 6 Jan 2017
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