International Journal of Public Health

, Volume 60, Issue 7, pp 839–848 | Cite as

Considering treatment of male genital schistosomiasis as a tool for future HIV prevention: a systematic review

  • Chalotte Willemann StecherEmail author
  • Per Kallestrup
  • Eyrun Floerecke Kjetland
  • Birgitte Vennervald
  • Eskild Petersen



Male genital schistosomiasis (MGS) is a neglected manifestation of Schistosoma haematobium infection with ignored implications on reproductive health and a differential diagnosis to sexually transmitted infections in endemic regions. MGS may have associations with HIV transmission and acquisition, and treatment could be a neglected chance of HIV prevention. This review summarizes current knowledge on epidemiology, clinical manifestations, diagnosis and treatment of MGS as a hypothesized risk factor for HIV transmission. Future research areas of global interest are suggested.


PubMed published literature was reviewed based on the MOOSE guidelines. All publications on MGS were included regardless of publication year and study design. Furthermore, all publications were searched for information on possible HIV association.


The 40 identified publications related to MGS were dominated by case reports and observational studies. No randomized clinical trials have been conducted to date, and very scant information related to possible associations with HIV transmission was presented.


Clinical, randomized studies and epidemiological studies covering the possible association between MGS and HIV are urgently needed. Furthermore, field diagnostic tools should be developed and future mass treatment programs should include adults to reduce morbidity and prevent HIV acquisition.

Systematic review registration number



Male Genital Schistosomiasis HIV MGS 



We would like to thank Dr. Merete Storgaard for her critical advice in the drafting of this manuscript. We also thank Janelle Denton for her grammar editing. Funding was provided by Aarhus University, Denmark.

Conflict of interest

The authors declare no conflicts of interest.


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Copyright information

© Swiss School of Public Health 2015

Authors and Affiliations

  1. 1.Department of Infectious DiseasesAarhus University HospitalAarhusDenmark
  2. 2.Center for Global Health (GloHAU)Aarhus UniversityAarhusDenmark
  3. 3.Norwegian Centre for Imported and Tropical DiseasesOslo University HospitalOsloNorway
  4. 4.Discipline of Public Health Medicine, Nelson R Mandela School of MedicineUniversity of KwaZulu-NatalDurbanSouth Africa
  5. 5.Department of Parasitology and Aquatic DiseasesUniversity of CopenhagenCopenhagenDenmark

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