International Journal of Public Health

, Volume 57, Issue 3, pp 569–579 | Cite as

Pandemic and seasonal vaccine coverage and effectiveness during the 2009–2010 pandemic influenza in an Italian adult population

  • Simona Costanzo
  • Francesco Gianfagna
  • Mariarosaria Persichillo
  • Francesca D Lucia
  • Angelita Verna
  • Modjenar Djidingar
  • Sara Magnacca
  • Francesca Bracone
  • Marco Olivieri
  • Maria Benedetta Donati
  • Giovanni de Gaetano
  • Licia Iacoviello
Original Article

Abstract

Objectives

To evaluate the response to pandemic vaccination and seasonal and pandemic vaccine effectiveness (VE) in an Italian adult population, during the 2009–2010 influenza season.

Methods

Data were recorded by interviewing 19,275 subjects (≥35 years), randomly recruited from the general population of the Moli-sani project. Events [influenza-like illness (ILI), hospitalization and death], which had occurred between 1 November 2009 and 31 January 2010 were considered. VE was analyzed by multivariable Poisson regression analysis.

Results

Pandemic vaccine coverage was very low (2.4%) in subjects at high-flu risk, aged 35–65 years (N = 8,048); there was no significant preventive effect of vaccine against ILI.

Seasonal vaccine coverage was 26.6% in the whole population (63% in elderly and 21.9% in middle-aged subjects at high-flu risk). There was a higher risk to develop ILI in middle-age [VE: −17% (95% CI: −35,−1)] or at high flu-risk [VE: −17% (95% CI: −39, 2)] vaccinated groups.

Conclusions

Coverage of pandemic vaccine was very low in a Southern Italy population, with no protective effect against ILI.

Keywords

Pandemic vaccine Seasonal vaccine Vaccine coverage Vaccine effectiveness Italian adults 

Notes

Acknowledgments

This study was funded by a European Vaccine Manufacturers grant through the Epiconcept society. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Copyright information

© Swiss School of Public Health 2012

Authors and Affiliations

  • Simona Costanzo
    • 1
  • Francesco Gianfagna
    • 1
  • Mariarosaria Persichillo
    • 1
  • Francesca D Lucia
    • 1
  • Angelita Verna
    • 1
  • Modjenar Djidingar
    • 1
  • Sara Magnacca
    • 1
  • Francesca Bracone
    • 1
  • Marco Olivieri
    • 1
  • Maria Benedetta Donati
    • 1
  • Giovanni de Gaetano
    • 1
  • Licia Iacoviello
    • 1
  1. 1.Laboratory of Genetic and Environmental Epidemiology, Research LaboratoriesFondazione di Ricerca e Cura “Giovanni Paolo II”CampobassoItaly

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