International Journal of Public Health

, Volume 55, Issue 4, pp 315–323 | Cite as

San Antonio heart study diabetes prediction model applicable to a Middle Eastern population? Tehran glucose and lipid study

  • Mohammadreza Bozorgmanesh
  • Farzad HadaeghEmail author
  • Azadeh Zabetian
  • Fereidoun Azizi
Original Article



To assess the validity of the San Antonio heart study (SAHS) diabetes prediction model in a large representative Iranian population.


A risk function derived from data in the SAHS to predict the 7.5-year risk of diabetes, was tested for its ability to predict incident diabetes in 3,242 individuals aged ≥20 years. The performance or ability to accurately predict diabetes risk, of the SAHS function compared with the performance of risk functions developed specifically from the Tehran lipid and glucose study. Comparisons included goodness of fit, discrimination, and calibration.


The participants were followed for 6.3 years. The area under the receiver operating characteristic curve (AROC) for diabetes of SAHS model was 0.83 (95% CI 0.80–0.86). The model overestimated the risk of diabetes in TLGS population with the overall bias of 111%. After the recalibration, the model-predicted probability agreed well with the actual observed 6-year risk of diabetes.

Discussion and conclusion

The American SAHS was a prediction model for diabetes with good discrimination in an Iranian target population after calibration.


Prediction Model Diabetes Validation General practice Screening 



This study was supported by grant No. 121 from the National Research Council of the Islamic Republic of Iran. We express our appreciation to the participants of district-13 of Tehran for their enthusiastic support in this study.

Conflict of interest statement



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Copyright information

© Swiss School of Public Health 2010

Authors and Affiliations

  • Mohammadreza Bozorgmanesh
    • 1
  • Farzad Hadaegh
    • 1
    Email author
  • Azadeh Zabetian
    • 1
  • Fereidoun Azizi
    • 1
  1. 1.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehranIslamic Republic of Iran

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