Cellular and Molecular Life Sciences CMLS

, Volume 56, Issue 7–8, pp 683–700

Intrathalamic sensory connections mediated by the thalamic reticular nucleus

  • J. W. Crabtree

DOI: 10.1007/s000180050462

Cite this article as:
Crabtree, J. CMLS, Cell. Mol. Life Sci. (1999) 56: 683. doi:10.1007/s000180050462

Abstract.

The thalamus and cerebral cortex are linked together to form a vast network of interconnections. Different modes of interactions among the cells in this network underlie different states of consciousness, such as wakefulness and sleep. Interposed between the dorsal thalamus and cortex are the GABAergic neurons of the thalamic reticular nucleus (TRN), which play a pivotal role not only in switching between the awake and sleep states but also in sensory processing during the awake state. The visual, somatosensory, and auditory sectors of TRN share many of the same organizational features. Each of these sectors contains maps, which are related to its inputs and outputs, and organizational components called ‘slabs.’ It is proposed that, during wakefulness, TRN is crucially involved in resetting the activity levels in sensory nuclei of the dorsal thalamus, which allows the cortex to actively and periodically compare its on-going sensory processing with the available sensory information.

Key words. Sensory processing; GABAergic neurons; reticular sectors; cortical projections; intrathalamic projections; organizational components; sensory maps; reticular discontinuities. 

Copyright information

© Birkhäuser Verlag Basel, 1999

Authors and Affiliations

  • J. W. Crabtree
    • 1
  1. 1.Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD (UK), Fax +44 117 929 1687, e-mail: J.W.Crabtree@bristol.ac.ukGB

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