Cellular and Molecular Life Sciences CMLS

, Volume 55, Issue 3, pp 437–449

Roles of the DNA mismatch repair and nucleotide excision repair proteins during meiosis

  • D. T. Kirkpatrick

DOI: 10.1007/s000180050300

Cite this article as:
Kirkpatrick, D. CMLS, Cell. Mol. Life Sci. (1999) 55: 437. doi:10.1007/s000180050300


Numerous proteins are involved in the nucleotide excision repair (NER) and DNA mismatch repair (MMR) pathways. The function and specificity of these proteins during the mitotic cell cycle has been actively investigated, in large part due to the involvement of these systems in human diseases. In contrast, comparatively little is known about their functioning during meiosis. At least three repair pathways operate during meiosis in the yeast Saccharomyces cerevisiae to repair mismatches that occur as a consequence of heteroduplex formation in recombination. The first pathway is similar to the one acting during postreplicative mismatch repair in mitotically dividing cells, while two pathways are responsible for the repair of large loops during meiosis, using proteins from MMR and NER systems. Some MMR proteins also help prevent recombination between diverged sequences during meiosis, and act late in recombination to affect the resolution of crossovers. This review will discuss the current status of DNA mismatch repair and nucleotide excision repair proteins during meiosis, especially in the yeast S. cerevisiae.

Key words. Meiosis; recombination; DNA mismatch repair; nucleotide excision repair; yeast. 

Copyright information

© Birkhäuser Verlag Basel, 1999

Authors and Affiliations

  • D. T. Kirkpatrick
    • 1
  1. 1.Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill (North Carolina, 27599-3280, USA), Fax +1 919 962 8472, e-mail: dtkirkpa@email.unc.eduUS

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