Cellular and Molecular Life Sciences CMLS

, Volume 55, Issue 3, pp 327–333 | Cite as

Immunotolerant functions of HLA-G

  • E. D. Carosella
  • J. Dausset
  • N. Rouas-Freiss

Abstract.

HLA-G is a nonclassical major histocompatibility complex class I molecule selectively expressed on cytotrophoblasts at the fetal-maternal interface, where it plays a role in materno-fetal tolerance. In contrast to classical HLA-A, -B and -C class I molecules, HLA-G is characterized by (i) a tissue-restricted distribution, (ii) a limited polymorphism and (iii) a transcription of spliced messenger RNAs encoding for at least four membrane-bound and two soluble HLA-G isoforms. Extensive studies over the past few years have identified HLA-G as a molecule involved in immune tolerance. In this review, attempts were made to summarize the current state of knowledge of the effects of HLA-G on both natural killer and T cell functions and their implications in materno-fetal tolerance and tumor immunosurveillance.

Key words. HLA-G; immunotolerance; killing inhibitory receptors; NK; T cells. 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Birkhäuser Verlag Basel, 1999

Authors and Affiliations

  • E. D. Carosella
    • 1
  • J. Dausset
    • 2
  • N. Rouas-Freiss
    • 1
  1. 1.Service de Recherches en Hémato-Immunologie, Commissariat à l’Energie Atomique-DRM-DSV, Hôpital Saint-Louis, Institut d’Hématologie, 1 avenue Claude-Vellefaux, F-75475 Paris cedex 10 (France), Fax +33 1 48 03 19 60, e-mail: carosella@dsvidf.cea.frFR
  2. 2.Fondation Jean Dausset, 27, rue Juliette-Dodu, F-75010 Paris cedex (France)FR

Personalised recommendations