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Cellular and Molecular Life Sciences CMLS

, Volume 55, Issue 1, pp 76–87 | Cite as

Covalent and noncovalent modifiers of the p53 protein

  • L. Jayaraman
  • C. Prives
Article

Abstract.

Despite the massive attention it has received, there is still much to learn about the p53 tumour suppressor protein. Given that it plays complex and multiple roles in cells, it is not surprising that p53 is subjected to an intricate array of regulatory processes. p53 receives signals from cells in multiple ways, leading to its stabilization and activation. The functions of the protein are altered by phosphorylation and other covalent modifications. However, a number of proteins can regulate p53 function dramatically by noncovalent means. p53 is thus subjected to numerous signalling and regulatory pathways which we have only begun to decipher.

Key words. Phosphorylation; DNA bending; redox; stabilization; signalling; C-terminus; N-terminus; modification; DNA binding. 

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Copyright information

© Birkhäuser-Verlag, Basel 1999

Authors and Affiliations

  • L. Jayaraman
    • 1
  • C. Prives
    • 1
  1. 1.Department of Biological Sciences, Columbia University, New York (New York 10027, USA), Fax +1 212 865 8246, e-mail: clp3@columbia.eduUS

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