Cellular and Molecular Life Sciences CMLS

, Volume 54, Issue 12, pp 1316–1329

Growth hormone-releasing peptide (GHRP)

  • C. Y. Bowers


Growth hormone-releasing peptides and non-peptides (GHRPs, GHRP-GHS) are a new chemical class of GH secretagogues with a chemistry that ranges from small synthetic peptides to peptidomimetics. They release GH in animals and humans by a unique dual and complementary action on the hypothalamus and pituitary. Although the present GHRPs are of unnatural origin, evidence by a number of investigators is gradually accumulating to support that GHRP reflects the GH-releasing action of a new natural hypothalamic hormone yet to be isolated and identified. Despite the de novo origin of GHRP, a major reason for the persistent investigation is because of the possible practical diagnostic and therapeutic value in humans as well as the potential theoretical value of new insight into the physiological regulation of GH secretion.

Key words. Growth hormone; GHRP; GHRH; SRIF; pituitary; hypothalamus; U-factor. 


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Copyright information

© Birkhäuser Verlag Basel, 1998

Authors and Affiliations

  • C. Y. Bowers
    • 1
  1. 1.Tulane University Medical School, 1430 Tulane Avenue, New Orleans (Louisiana 70112, USA), Fax +1 504 587 4282, e-mail: rjabower@tmcpop.tmc.tulane.eduUS

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