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Cellular and Molecular Life Sciences CMLS

, Volume 54, Issue 7, pp 641–652 | Cite as

The role of peroxisomes in aging

  • R. Périchon
  • J. M. Bourre
  • J. F. Kelly
  • G. S. Roth

Abstract.

Reactive oxygen species and alterations in membrane lipid homeostasis are thought to be important events in aging process and aging-related degenerative diseases. The peroxisome is a small cellular organelle involved in both oxygen and lipid metabolism, and defects in peroxisomal function are associated with major, and often fatal, changes at the neurological level during human development. Recent reports of aging-related changes in peroxisomal function raised the hypothesis that peroxisomes may also have a significant role in the aging process and aging-related degenerative diseases. This review presents the current data on changes in peroxisomal function during aging and discusses the implications of these changes for health.

Key words. Peroxisome; aging; lipid metabolism; oxidative stress. 

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Copyright information

© Birkhäuser Verlag Basel, 1998

Authors and Affiliations

  • R. Périchon
    • 1
  • J. M. Bourre
    • 2
  • J. F. Kelly
    • 1
  • G. S. Roth
    • 1
  1. 1.Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 4940 Eastern Avenue, Baltimore (Maryland 21224, USA), Fax +1 410 558 8323, e-mail: perichor@grc.nia.nih.govUS
  2. 2.INSERM U26, Laboratoire de Neuro-Pharmaco-Nutrition, Hôpital Fernand Widal, 200 rue du Faubourg Saint-Denis, F-75475 Paris Cedex 10 (France)FR

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