Cellular and Molecular Life Sciences CMLS

, Volume 54, Issue 3, pp 282–287 | Cite as

Central IL-1 differentially regulates peripheral IL-6 and TNF synthesis

  • H. Kitamura
  • S. Okamoto
  • Y. Shimamoto
  • M. Morimatsu
  • A. Terao
  • M. Saito
Article

Abstract

Centrally given interleukin (IL)-1 is known to induce a rapid rises in blood IL-6. To extend this and to examine the mechanism by which this occurs, the effects of intracerebroventricular (icv) injection of human recombinant IL-1β on mRNA expression of IL-6 and tumour necrosis factor (TNF) in the spleen and liver were examined in rats. Icv injection of IL-1 produced a rapid rise of the tissue mRNA levels of IL-6 and TNF in both organs, prior to and/or in parallel with an increase in their serum levels. Pretreatment with chlorisondamine, a ganglionic blocking agent, inhibited the IL-6 responses, while it had little influence on the TNF responses. The results suggest that brain IL-1 induces peripheral production of IL-6, but not of TNF, through autonomic nervous system activation.

Key words. Interleukin-1 (IL-1); interleukin-6 (IL-6); tumour necrosis factor (TNF); autonomic nervous system; cytokine. 

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Copyright information

© Birkhäuser-Verlag, Basel 1998

Authors and Affiliations

  • H. Kitamura
    • 1
  • S. Okamoto
    • 1
  • Y. Shimamoto
    • 2
  • M. Morimatsu
    • 1
  • A. Terao
    • 1
  • M. Saito
    • 1
  1. 1.Laboratory of Biochemistry, Department of Biomedical Sciences, School of Veterinary Medicine, Hokkaido University, Sapporo 060 (Japan), Fax +81 11 757 0703, e-mail: saito@vetmed.hokudai.ac.jpJP
  2. 2.Laboratory of Toxicology, Department of Environmental Veterinary Medical Sciences, School of Veterinary Medicine, Hokkaido University, Sapporo (Japan)JP

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