Advertisement

Cellular and Molecular Life Sciences CMLS

, Volume 54, Issue 1, pp 50–59 | Cite as

Time out: developmental regulation of heterochromatic silencing in Drosophila

  • B. Y. Lu
  • J. C. Eissenberg

Abstract.

Transcriptional silencing by heterochromatin represents a model for developmental gene silencing. Current models of heterochromatin envision DNA-protein complexes that prevent access by euchromatic transcription factors. Here, we summarize the evidence that heterochromatin acts at the chromatin level to silence genes and the status of current models of heterochromatin silencing, and we highlight some recent progress in understanding the composition and regulation of heterochromatin in Drosophila.

Key words. Heterochromatin; position-effect variegation; Drosophila; epigenetic; silencing; development. 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Birkhäuser Verlag Basel, 1998

Authors and Affiliations

  • B. Y. Lu
    • 1
  • J. C. Eissenberg
    • 2
  1. 1.Cell and Molecular Biology Program, Saint Louis University Health Sciences Center, 1402 South Grand Blvd., St. Louis (Missouri 63104, USA)US
  2. 2.Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University Health Sciences Center, 1402 South Grand Blvd., St. Louis (Missouri 63104, USA), Fax +314 577 8156, e-mail: eissenjc@wpogate.slu.eduUS

Personalised recommendations