Cellular and Molecular Life Sciences CMLS

, Volume 53, Issue 6, pp 533–538

Annexins in the secretory pathway

  • S. R. Donnelly
  • S. E. Moss

DOI: 10.1007/s000180050068

Cite this article as:
Donnelly, S. & Moss, S. CMLS, Cell. mol. life sci. (1997) 53: 533. doi:10.1007/s000180050068


Among the multiplicity of roles suggested for proteins of the annexin family, those implicating these proteins in regulated exocytosis remain among the most convincing. Studies in this area of annexin biology have focused on annexin II, which because of its unusually low Ca2+-requirement for phospholipid-binding has many of the requisite properties of a membrane fusogenic Ca2+ sensor. Other annexins are also good candidates for exocytotic mediators, especially annexins I and VII, which have strong vesicle-aggregating activities. In contrast, annexin VI appears to block vesicle aggregation, perhaps acting as a negative regulator of exocytosis. In this review, we consider the evidence for and against annexins having functions in the secretory pathway.

Key words. Annexin; secretion; vesicle; exocytosis; calcium; neutrophil; chromaffin cell. 

Copyright information

© Birkhäuser Verlag Basel, 1997

Authors and Affiliations

  • S. R. Donnelly
    • 1
  • S. E. Moss
    • 1
  1. 1.Department of Physiology, University College London, Gower Street, London WC1E 6BT (UK), Fax +44 171 413 8395, e-mail: s.moss@ucl.ac.ukGB

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