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Systems biology: current status and challenges

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Abstract

We put together a special issue on current approaches in systems biology with a focus on mathematical modeling of metabolic networks. Mathematical models have increasingly been used to unravel molecular mechanisms of complex dynamic biological processes. We here provide a short introduction into the topics covered in this special issue, highlighting current developments and challenges.

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Correspondence to Ines Heiland.

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Zupanic, A., Bernstein, H.C. & Heiland, I. Systems biology: current status and challenges. Cell. Mol. Life Sci. (2020) doi:10.1007/s00018-019-03410-z

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Keywords

  • Systems biology
  • Mathematical modeling
  • Metabolic pathway analysis
  • Network dynamics
  • Multi-scale modeling