We put together a special issue on current approaches in systems biology with a focus on mathematical modeling of metabolic networks. Mathematical models have increasingly been used to unravel molecular mechanisms of complex dynamic biological processes. We here provide a short introduction into the topics covered in this special issue, highlighting current developments and challenges.
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Zupanic, A., Bernstein, H.C. & Heiland, I. Systems biology: current status and challenges. Cell. Mol. Life Sci. (2020) doi:10.1007/s00018-019-03410-z
- Systems biology
- Mathematical modeling
- Metabolic pathway analysis
- Network dynamics
- Multi-scale modeling