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CircRNA: a rising star in gastric cancer

  • Rong Li
  • Jiajia Jiang
  • Hui Shi
  • Hui Qian
  • Xu ZhangEmail author
  • Wenrong XuEmail author
Review
  • 41 Downloads

Abstract

In recent years, a large number of circRNAs have been identified in mammalian cells with high-throughput sequencing technologies and bioinformatics. The aberrant expression of circRNAs has been reported in many human diseases including gastric cancer (GC). The number of GC-related circRNAs with validated biological functions and mechanisms of action is growing. CircRNAs are critically involved in GC cell proliferation, apoptosis, migration, and invasion. CircRNAs have been shown to function as regulators of parental gene transcription and alternative splicing and miRNA sponges. Moreover, circRNAs have been suggested to interact with proteins to regulate their expression level and activities. Several circRNAs have been identified to encode functional proteins. Due to their great abundance, high stability, tissue- and developmental-stage-specific expression patterns, and wide distribution in various body fluids and exosomes, circRNAs exhibit a great potential to be utilized as biomarkers for GC. Herein, we briefly summarize their biogenesis, properties and biological functions and discuss about the current research progress of circRNAs in GC with a focus on the potential application for GC diagnosis and therapy.

Keywords

CircRNA Gastric cancer miRNA sponge Biomarker Therapeutic target 

Abbreviations

GC

Gastric cancer

EcircRNAs

Exonic circRNAs

CiRNAs

Intronic circRNAs

EIciRNAs

Exon–intron circular RNAs

TricRNAs

TRNA intronic circRNAs

MBL

Muscleblind

A-to-I

Adenosine-to-Inosine

QKI

Quaking

EMT

Epithelial-mesenchymal transition

RBPs

RNA-binding proteins

TSEN

TRNA splicing endonuclease complex

BHB

Bulge–helix–bulge

HCC

Hepatocellular carcinoma

ESCC

Esophageal squamous cell carcinoma

IRES

Internal ribosome entry sites

CDK2

Cyclin-dependent kinase 2

M6A

N6-methyladenosine

PES1

Pescadillo homologue 1

AGO2

Argonauto 2

AUC

Area under the ROC curve

Ex-circRNAs

Exosomes-derived circRNAs

CAFs

Cancer-associated fibroblasts

SiRNAs

Small interfering RNAs

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant 81572075, Grant 81972310), Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and Transformation Application (Grant SS2018003), and Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

Author contributions

RL and JJ collected literature and draft the manuscript. HS, XZ, HQ and WX reviewed and made significant revisions to the manuscript. All authors have read and approved the final manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Aoyang Institute of CancerJiangsu UniversitySuzhouChina
  2. 2.Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and Transformation Application, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of MedicineJiangsu UniversityZhenjiangChina

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