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Progress on chicken T cell immunity to viruses

  • Manman Dai
  • Chenggang Xu
  • Weisan ChenEmail author
  • Ming LiaoEmail author
Review
  • 8 Downloads

Abstract

Avian virus infection remains one of the most important threats to the poultry industry. Pathogens such as avian influenza virus (AIV), avian infectious bronchitis virus (IBV), and infectious bursal disease virus (IBDV) are normally controlled by antibodies specific for surface proteins and cellular immune responses. However, standard vaccines aimed at inducing neutralizing antibodies must be administered annually and can be rendered ineffective because immune-selective pressure results in the continuous mutation of viral surface proteins of different strains circulating from year to year. Chicken T cells have been shown to play a crucial role in fighting virus infection, offering lasting and cross-strain protection, and offer the potential for developing universal vaccines. This review provides an overview of our current knowledge of chicken T cell immunity to viruses. More importantly, we point out the limitations and barriers of current research and a potential direction for future studies.

Keywords

Chicken CD8+ T cell response CD4+ T cell response Virus Epitope 

Notes

Author contributions

MMD drafted the manuscript. WSC, ML, and CGX revised the manuscript.

Funding

This work was supported by the National Natural Science Foundation Grants (31802174 and 31830097) and a China Postdoctoral Science Foundation Grant (2018M630956).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of financial interest.

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Authors and Affiliations

  1. 1.College of Veterinary MedicineSouth China Agricultural UniversityGuangzhouPeople’s Republic of China
  2. 2.T Cell Lab, Department of Biochemistry and Genetics, La Trobe Institute of Molecular ScienceLa Trobe UniversityBundooraAustralia
  3. 3.National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and ControlGuangzhouPeople’s Republic of China
  4. 4.Key Laboratory of Veterinary Vaccine Innovation of the Ministry of AgricultureGuangzhouPeople’s Republic of China
  5. 5.Key Laboratory of Zoonosis Prevention and Control of Guangdong ProvinceGuangzhouPeople’s Republic of China

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