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Therapeutic potential of menstrual blood-derived endometrial stem cells in cardiac diseases

  • Yanli Liu
  • Rongcheng Niu
  • Wenzhong LiEmail author
  • Juntang LinEmail author
  • Christof Stamm
  • Gustav Steinhoff
  • Nan Ma
Review
  • 52 Downloads

Abstract

Despite significant developments in medical and surgical strategies, cardiac diseases remain the leading causes of morbidity and mortality worldwide. Numerous studies involving preclinical and clinical trials have confirmed that stem cell transplantation can help improve cardiac function and regenerate damaged cardiac tissue, and stem cells isolated from bone marrow, heart tissue, adipose tissue and umbilical cord are the primary candidates for transplantation. During the past decade, menstrual blood-derived endometrial stem cells (MenSCs) have gradually become a promising alternative for stem cell-based therapy due to their comprehensive advantages, which include their ability to be periodically and non-invasively collected, their abundant source material, their ability to be regularly donated, their superior proliferative capacity and their ability to be used for autologous transplantation. MenSCs have shown positive therapeutic potential for the treatment of various diseases. Therefore, aside from a brief introduction of the biological characteristics of MenSCs, this review focuses on the progress being made in evaluating the functional improvement of damaged cardiac tissue after MenSC transplantation through preclinical and clinical studies. Based on published reports, we conclude that the paracrine effect, transdifferentiation and immunomodulation by MenSC promote both regeneration of damaged myocardium and improvement of cardiac function.

Keywords

Cardiac regeneration Stem cell-based therapy Menstrual blood-derived endometrial stem cells Cardiac disease 

Notes

Acknowledgements

We would like to acknowledge the China Scholarship Council, the National Natural Science Foundation of China (81671619 and 81771226) and the Xinxiang Foundation (20172DCG-03 and ZD17008) for their financial support.

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest regarding the publication of this paper.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Stem Cell and Biotherapy Technology Research Center, College of Life Science and Technology, Henan Key Laboratory of Medical Tissue RegenerationXinxiang Medical UniversityXinxiangPeople’s Republic of China
  2. 2.Institute of Chemistry and BiochemistryFree University BerlinBerlinGermany
  3. 3.Deutsches Herzzentrum Berlin (DHZB)BerlinGermany
  4. 4.German Center for Cardiovascular Research (DZHK)BerlinGermany
  5. 5.Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu BerlinBerlinGermany
  6. 6.Berlin Institute of HealthBerlinGermany
  7. 7.Department of Cardiac Surgery, Reference and Translation Center for Cardiac Stem Cell TherapyUniversity RostockRostockGermany
  8. 8.Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative TherapiesHelmholtz-Zentrum GeesthachtTeltowGermany

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