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Disassembly of dying cells in diverse organisms

  • Rochelle Tixeira
  • Ivan K. H. Poon
Review

Abstract

Programmed cell death (PCD) is a conserved phenomenon in multicellular organisms required to maintain homeostasis. Among the regulated cell death pathways, apoptosis is a well-described form of PCD in mammalian cells. One of the characteristic features of apoptosis is the change in cellular morphology, often leading to the fragmentation of the cell into smaller membrane-bound vesicles through a process called apoptotic cell disassembly. Interestingly, some of these morphological changes and cell disassembly are also noted in cells of other organisms including plants, fungi and protists while undergoing ‘apoptosis-like PCD’. This review will describe morphologic features leading to apoptotic cell disassembly, as well as its regulation and function in mammalian cells. The occurrence of cell disassembly during cell death in other organisms namely zebrafish, fly and worm, as well as in other eukaryotic cells will also be discussed.

Keywords

Apoptotic bodies Extracellular vesicles Apoptosis Apoptosis-like PCD Blebbing Membrane protrusions 

Notes

Acknowledgements

We would like to thank the Poon Laboratory for discussion. This work was supported by Grants from the National Health & Medical Research Council of Australia (GNT1125033 and GNT1140187) to I.K.H.P.

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Biochemistry and Genetics, La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneAustralia

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