Cellular and Molecular Life Sciences

, Volume 75, Issue 18, pp 3339–3351 | Cite as

Trans-spliced long non-coding RNA: an emerging regulator of pluripotency

  • Chun-Ying Yu
  • Ching-Yu Chuang
  • Hung-Chih KuoEmail author


With dual capacities for unlimited self-renewal and pluripotent differentiation, pluripotent stem cells (PSCs) give rise to many cell types in our body and PSC culture systems provide an unparalleled opportunity to study early human development and disease. Accumulating evidence indicates that the molecular mechanisms underlying pluripotency maintenance in PSCs involve many factors. Among these regulators, recent studies have shown that long non-coding RNAs (lncRNAs) can affect the pluripotency circuitry by cooperating with master pluripotency-associated factors. Additionally, trans-spliced RNAs, which are generated by combining two or more pre-mRNA transcripts to produce a chimeric RNA, have been identified as regulators of various biological processes, including human pluripotency. In this review, we summarize and discuss current knowledge about the roles of lncRNAs, including trans-spliced lncRNAs, in controlling pluripotency.


Trans-spliced RNA Pluripotency Human embryonic stem cells Long non-coding RNAs Induced pluripotent stem cells 



This work was supported by Grants from Academia Sinica (Thematic Project, AS-104-TP-B09 and AS-103-TP-B10) and the Ministry of Science and Technology (MOST104-0210-01-09-02/105-0210-01-13-01/106-0210-01-15-02/106-2321-B-001-049-MY3) and National Health Research Institutes (HRI-EX104-10320SI).


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Chun-Ying Yu
    • 1
  • Ching-Yu Chuang
    • 2
  • Hung-Chih Kuo
    • 1
    • 2
    • 3
    Email author
  1. 1.Institute of Cellular and Organismic BiologyAcademia SinicaTaipeiTaiwan
  2. 2.Genomics Research CenterAcademia SinicaTaipeiTaiwan
  3. 3.College of Medicine, Graduate Institute of Medical Genomics and ProteomicsNational Taiwan UniversityTaipeiTaiwan

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