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Regulation of the Hippo pathway in cancer biology

Abstract

The Hippo tumor suppressor pathway, which is well conserved from Drosophila to humans, has emerged as the master regulator of organ size, as well as major cellular properties, such as cell proliferation, survival, stemness, and tissue homeostasis. The biological significance and deregulation of the Hippo pathway in tumorigenesis have received a surge of interest in the past decade. In the current review, we present the major discoveries that made substantial contributions to our understanding of the Hippo pathway and discuss how Hippo pathway components contribute to cellular signaling, physiology, and their potential implications in anticancer therapeutics.

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Acknowledgements

We apologize to those colleagues, whose work has not been cited because of space limitations. This work was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (Grant Number: HI17C1560), and the National Research Foundation of Korea (NRF) Grant funded by the Korea government (2017R1A4A1015328 and 2018R1C1B6004301), and funded by the Yonsei University Future-leading Research Initiative of 2017 (2017-22-0071) to H.W.P. In addition, S.H.M and S.Y.P were supported by the Brain Korea (BK21) PLUS Program.

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Correspondence to Hyun Woo Park.

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Moon, S., Yeon Park, S. & Woo Park, H. Regulation of the Hippo pathway in cancer biology. Cell. Mol. Life Sci. 75, 2303–2319 (2018) doi:10.1007/s00018-018-2804-1

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Keywords

  • Hippo pathway
  • YAP/TAZ
  • TEAD
  • Cancer
  • Therapeutic target