Shaping the cellular landscape with Set2/SETD2 methylation



Chromatin structure is a major barrier to gene transcription that must be disrupted and re-set during each round of transcription. Central to this process is the Set2/SETD2 methyltransferase that mediates co-transcriptional methylation to histone H3 at lysine 36 (H3K36me). Studies reveal that H3K36me not only prevents inappropriate transcriptional initiation from arising within gene bodies, but that it has other conserved functions that include the repair of damaged DNA and regulation of pre-mRNA splicing. Consistent with the importance of Set2/SETD2 in chromatin biology, mutations of SETD2, or mutations at or near H3K36 in H3.3, have recently been found to underlie cancer development. This review will summarize the latest insights into the functions of Set2/SETD2 in genome regulation and cancer development.


Histone H3K36 methylation Set2 SETD2 Transcriptional regulation Cryptic transcription 

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© Springer International Publishing 2017

Authors and Affiliations

  1. 1.Department of Biomolecular ChemistryUniversity of WisconsinMadisonUSA
  2. 2.Curriculum in Genetics and Molecular BiologyUniversity of North CarolinaChapel HillUSA
  3. 3.Department of BiochemistryUniversity of North CarolinaChapel HillUSA
  4. 4.Lineberger Comprehensive Cancer CenterUniversity of North CarolinaChapel HillUSA

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