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Cellular and Molecular Life Sciences

, Volume 74, Issue 14, pp 2587–2600 | Cite as

Effect of hypoxia on human adipose-derived mesenchymal stem cells and its potential clinical applications

Review

Abstract

Human adipose-derived mesenchymal stem cells (hASCs) are an ideal cell source for regenerative medicine due to their capabilities of multipotency and the readily accessibility of adipose tissue. They have been found residing in a relatively low oxygen tension microenvironment in the body, but the physiological condition has been overlooked in most studies. In light of the escalating need for culturing hASCs under their physiological condition, this review summarizes the most recent advances in the hypoxia effect on hASCs. We first highlight the advantages of using hASCs in regenerative medicine and discuss the influence of hypoxia on the phenotype and functionality of hASCs in terms of viability, stemness, proliferation, differentiation, soluble factor secretion, and biosafety. We provide a glimpse of the possible cellular mechanism that involved under hypoxia and discuss the potential clinical applications. We then highlight the existing challenges and discuss the future perspective on the use of hypoxic-treated hASCs.

Keywords

Hypoxia hASCs Phenotype Functionality Clinical applications Challenges 

Notes

Acknowledgements

The work was supported by the UM High Impact Research Grant UM-MOHE (UM.C/HIR/MOHE/ENG/44) from the Ministry of Higher Education Malaysia and the University of Malaya Research Grant (UMRG: RP040B-15HTM).

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Copyright information

© Springer International Publishing 2017

Authors and Affiliations

  1. 1.Department of Biomedical Engineering, Faculty of EngineeringUniversity of MalayaKuala LumpurMalaysia

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