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Liposarcoma: molecular targets and therapeutic implications

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Abstract

Liposarcoma (LPS) is the most common soft tissue sarcoma and accounts for approximately 20 % of all adult sarcomas. Current treatment modalities (surgery, chemotherapy, and radiotherapy) all have limitations; therefore, molecularly driven studies are needed to improve the identification and increased understanding of genetic and epigenetic deregulations in LPS if we are to successfully target specific tumorigenic drivers. It can be anticipated that such biology-driven therapeutics will improve treatments by selectively deleting cancer cells while sparing normal tissues. This review will focus on several therapeutically actionable molecular markers identified in well-differentiated LPS and dedifferentiated LPS, highlighting their potential clinical applicability.

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Acknowledgments

The authors would like to acknowledge Dr. Julie Bridge from the Department of Pathology, University of Nebraska who graciously provided the Fluorescence In Situ Hybridization (FISH) image.

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    Authors and Affiliations

    1. The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

      Kate Lynn J. Bill, Lucia Casadei, Bethany C. Prudner, Hans Iwenofu, Anne M. Strohecker & Raphael E. Pollock

    2. Division of Surgical Oncology, Department of Surgery, Wexner Medical Center, The Ohio State University, 410W 10th Ave., Columbus, OH, 43210, USA

      Kate Lynn J. Bill, Lucia Casadei, Bethany C. Prudner, Anne M. Strohecker & Raphael E. Pollock

    3. Department of Pathology, The Ohio State University, Columbus, OH, USA

      Hans Iwenofu

    4. Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH, USA

      Anne M. Strohecker

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    This review was supported by the NCI U54CA168512 to REP.

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    K. L. J. Bill and L. Casadei have contributed equally.

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    Bill, K.L.J., Casadei, L., Prudner, B.C. et al. Liposarcoma: molecular targets and therapeutic implications. Cell. Mol. Life Sci. 73, 3711–3718 (2016). https://doi.org/10.1007/s00018-016-2266-2

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