Cellular and Molecular Life Sciences

, Volume 73, Issue 17, pp 3337–3349 | Cite as

Intestinal stem cell response to injury: lessons from Drosophila

  • Huaqi Jiang
  • Aiguo Tian
  • Jin Jiang


Many adult tissues and organs are maintained by resident stem cells that are activated in response to injury but the mechanisms that regulate stem cell activity during regeneration are still poorly understood. An emerging system to study such problem is the Drosophila adult midgut. Recent studies have identified both intrinsic factors and extrinsic niche signals that control the proliferation, self-renewal, and lineage differentiation of Drosophila adult intestinal stem cells (ISCs). These findings set up the stage to interrogate how niche signals are regulated and how they are integrated with cell-intrinsic factors to control ISC activity during normal homeostasis and regeneration. Here we review the current understanding of the mechanisms that control ISC self-renewal, proliferation, and lineage differentiation in Drosophila adult midgut with a focus on the niche signaling network that governs ISC activity in response to injury.


ISC midgut Wnt Wg Hedgehog Hh BMP Dpp Gbb EGFR Ras Hippo Yki Yap JAK-STAT JNK Notch Insulin InR Calcium microRNA Aging Tissue damage Self-renewal Symmetric division Asymmetric division Proliferation Regeneration Tumor 



This work is supported by grants from NIH (GM106188, and GM118063) and Welch Foundation (I-1603) to Jin Jiang (J, J). Huaqi Jiang (H.J) is supported by a grant from NIH (DK102576). JJ is a Eugene McDermott Endowed Scholar in Biomedical Science at UT Southwestern Medical Center.


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Copyright information

© Springer International Publishing 2016

Authors and Affiliations

  1. 1.Department of Molecular BiologyUniversity of Texas Southwestern Medical Center at DallasDallasUSA
  2. 2.Department of PharmacologyUniversity of Texas Southwestern Medical Center at DallasDallasUSA

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