Cellular and Molecular Life Sciences

, Volume 73, Issue 6, pp 1225–1236 | Cite as

Exploring NAD+ metabolism in host–pathogen interactions

  • Inês Mesquita
  • Patrícia Varela
  • Ana Belinha
  • Joana Gaifem
  • Mireille Laforge
  • Baptiste Vergnes
  • Jérôme Estaquier
  • Ricardo Silvestre
Review

Abstract

Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. The regulation of NAD+ metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. Increasing interest has been given to NAD+ metabolism during innate and adaptive immune responses suggesting that its modulation could also be relevant during host–pathogen interactions. While the maintenance of NAD+ homeostatic levels assures an adequate environment for host cell survival and proliferation, fluctuations in NAD+ or biosynthetic precursors bioavailability have been described during host–pathogen interactions, which will interfere with pathogen persistence or clearance. Here, we review the double-edged sword of NAD+ metabolism during host–pathogen interactions emphasizing its potential for treatment of infectious diseases.

Keywords

Nicotinamide adenine dinucleotide (NAD+Host-pathogen interaction NAD+/NADH ratio NADPH Sirtuins l-tryptophan 

Notes

Acknowledgments

JG was supported by PD/BD/106053/2015. BV was supported by IRD (Institut de Recherche pour le Développement) institutional funding. JE was supported by a European Community’s Seventh Framework Program under grant agreement No. 602773 (Project KINDRED), an ANR grant (LEISH-APO, France) and a Partenariat Hubert Curien (PHC) (program Volubilis, MA/11/262). JE also thanks the Canada Research Chair program for his support. RS thank FCT—Foundation for Science and Technology—for their Investigator FCT Grant (IF/00021/2014)

Compliance with ethical standards

Conflict of interest

The authors have declared that no competing interests exist.

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Copyright information

© Springer International Publishing 2015

Authors and Affiliations

  • Inês Mesquita
    • 1
    • 2
  • Patrícia Varela
    • 1
    • 2
  • Ana Belinha
    • 1
    • 2
  • Joana Gaifem
    • 1
    • 2
  • Mireille Laforge
    • 4
  • Baptiste Vergnes
    • 3
  • Jérôme Estaquier
    • 4
    • 5
  • Ricardo Silvestre
    • 1
    • 2
  1. 1.Microbiology and Infection Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health SciencesUniversity of MinhoBragaPortugal
  2. 2.ICVS/3B’s-PT Government Associate LaboratoryBraga/GuimarãesPortugal
  3. 3.MIVEGEC (IRD 224-CNRS 5290-Université Montpellier)Institut de Recherche pour le Développement (IRD)MontpellierFrance
  4. 4.CNRS FR 3636Université Paris DescartesParisFrance
  5. 5.Centre de Recherche du CHU de QuébecUniversité LavalQuebecCanada

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