Cellular and Molecular Life Sciences

, Volume 73, Issue 3, pp 497–521 | Cite as

Circadian mRNA expression: insights from modeling and transcriptomics

Review

Abstract

Circadian clocks synchronize organisms to the 24 h rhythms of the environment. These clocks persist under constant conditions, have their origin at the cellular level, and produce an output of rhythmic mRNA expression affecting thousands of transcripts in many mammalian cell types. Here, we review the charting of circadian output rhythms in mRNA expression, focusing on mammals. We emphasize the challenges in statistics, interpretation, and quantitative descriptions that such investigations have faced and continue to face, and outline remaining outstanding questions.

Keywords

Circadian mRNA expression Post-transcriptional regulation Systems biology Biostatistics 

Supplementary material

18_2015_2072_MOESM1_ESM.xlsx (7 kb)
Supplementary material 1 (XLSX 7 kb)
18_2015_2072_MOESM2_ESM.nb (200 kb)
Supplementary material 2 (NB 201 kb)

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© Springer Basel 2015

Authors and Affiliations

  1. 1.Institute for Theoretical BiologyCharité – Universitätsmedizin BerlinBerlinGermany

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