Cellular and Molecular Life Sciences

, Volume 73, Issue 2, pp 291–303 | Cite as

Sonic hedgehog patterning during cerebellar development

  • Annarita De Luca
  • Valentina Cerrato
  • Elisa Fucà
  • Elena Parmigiani
  • Annalisa Buffo
  • Ketty Leto
Review

Abstract

The morphogenic factor sonic hedgehog (Shh) actively orchestrates many aspects of cerebellar development and maturation. During embryogenesis, Shh signaling is active in the ventricular germinal zone (VZ) and represents an essential signal for proliferation of VZ-derived progenitors. Later, Shh secreted by Purkinje cells sustains the amplification of postnatal neurogenic niches: the external granular layer and the prospective white matter, where excitatory granule cells and inhibitory interneurons are produced, respectively. Moreover, Shh signaling affects Bergmann glial differentiation and promotes cerebellar foliation during development. Here we review the most relevant functions of Shh during cerebellar ontogenesis, underlying its role in physiological and pathological conditions.

Keywords

Shh Mitogen Differentiation Cerebellum 

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Copyright information

© Springer Basel 2015

Authors and Affiliations

  • Annarita De Luca
    • 1
    • 2
  • Valentina Cerrato
    • 1
    • 2
  • Elisa Fucà
    • 1
    • 2
  • Elena Parmigiani
    • 1
    • 2
  • Annalisa Buffo
    • 1
    • 2
  • Ketty Leto
    • 1
    • 2
  1. 1.Department of Neuroscience Rita Levi-MontalciniUniversity of TurinTurinItaly
  2. 2.Neuroscience Institute Cavalieri OttolenghiOrbassano, TurinItaly

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