Cellular and Molecular Life Sciences

, Volume 72, Issue 9, pp 1759–1777 | Cite as

Metabolic restructuring and cell fate conversion

  • Alessandro Prigione
  • María Victoria Ruiz-Pérez
  • Raul Bukowiecki
  • James Adjaye
Review
First Online:
Received:
Revised:
Accepted:

Abstract

Accumulating evidence implicates mitochondrial and metabolic pathways in the establishment of pluripotency, as well as in the control of proliferation and differentiation programs. From classic studies in mouse embryos to the latest findings in adult stem cells, human embryonic and induced pluripotent stem cells, an increasing number of evidence suggests that mitochondrial and metabolic-related processes might intertwine with signaling networks and epigenetic rewiring, thereby modulating cell fate decisions. This review summarizes the progresses in this exciting field of research. Dissecting these complex mitochondrial and metabolic mechanisms may lead to a more comprehensive understanding of stemness biology and to potential improvements in stem cell applications for biomedicine, cell therapy, and disease modeling.

Keywords

iPSCs Mitochondria Metabolism Stem cells Reprogramming Pluripotency 
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Notes

Acknowledgments

The authors declare no competing financial or commercial interests. M.V.R.P. is financed by CVI-06585 (Junta de Andalucía, Spain). R.B. receives a fellowship support from the MDC-PhD Program. A.P. acknowledges support from the Deutsche Forschungsgemeinschaft (DFG). J.A. acknowledges partial support from the European Union funding/FP7 (FP7/2007-2013)/Grant Agreement n° 305299 (AgedBrainSYSBIO), BMBF grant (10GN1005) and from the medical faculty of the Heinrich Heine University-Düsseldorf.

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Copyright information

© Springer Basel 2015

Authors and Affiliations

  • Alessandro Prigione
    • 1
  • María Victoria Ruiz-Pérez
    • 2
  • Raul Bukowiecki
    • 1
  • James Adjaye
    • 3
  1. 1.Max Delbrueck Center for Molecular Medicine (MDC)BerlinGermany
  2. 2.Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga)Universidad de MálagaMálagaSpain
  3. 3.Institute for Stem Cell Research and Regenerative MedicineHeinrich Heine UniversityDuesseldorfGermany

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