Cellular and Molecular Life Sciences

, Volume 71, Issue 22, pp 4421–4430 | Cite as

DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist

  • Leonidas Benetatos
  • George Vartholomatos
  • Eleftheria Hatzimichael
Review

Abstract

DLK1-DIO3 represents an imprinted cluster which genes are involved in physiological cell biology as early as the stem cell level and in the pathogenesis of several diseases. Transcription factor-mediated induced pluripotent cells (iPSCs) are considered an unlimited source of patient-specific hematopoietic stem cells for clinical application in patient-tailored regenerative medicine. However, to date there is no marker established able to distinguish embryonic stem cell-equivalent iPSCs or safe human iPSCs. Recent findings suggest that the DLK1-DIO3 locus possesses the potential to represent such a marker but there are also contradictory data. This review aims to report the current data on the topic describing both sides of the coin.

Keywords

DLK1-DIO3 MEG3 Pluripotency Genomic imprinting MicroRNAs Stem cells Reprogramming Induced pluripotent stem cells 

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Copyright information

© Springer Basel 2014

Authors and Affiliations

  • Leonidas Benetatos
    • 1
  • George Vartholomatos
    • 2
  • Eleftheria Hatzimichael
    • 3
  1. 1.Blood Bank, Selefkeias 2Preveza General HospitalPrevezaGreece
  2. 2.Molecular Biology LaboratoryIoannina University HospitalIoanninaGreece
  3. 3.Department of HematologyIoannina University HospitalIoanninaGreece

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