Cellular and Molecular Life Sciences

, Volume 71, Issue 22, pp 4421–4430 | Cite as

DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist

  • Leonidas BenetatosEmail author
  • George Vartholomatos
  • Eleftheria Hatzimichael


DLK1-DIO3 represents an imprinted cluster which genes are involved in physiological cell biology as early as the stem cell level and in the pathogenesis of several diseases. Transcription factor-mediated induced pluripotent cells (iPSCs) are considered an unlimited source of patient-specific hematopoietic stem cells for clinical application in patient-tailored regenerative medicine. However, to date there is no marker established able to distinguish embryonic stem cell-equivalent iPSCs or safe human iPSCs. Recent findings suggest that the DLK1-DIO3 locus possesses the potential to represent such a marker but there are also contradictory data. This review aims to report the current data on the topic describing both sides of the coin.


DLK1-DIO3 MEG3 Pluripotency Genomic imprinting MicroRNAs Stem cells Reprogramming Induced pluripotent stem cells 



We would like to thank Nikolaos Benetatos MD for his helpful comments. We apologize to those authors whose work has not been cited.

Conflict of interest



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Copyright information

© Springer Basel 2014

Authors and Affiliations

  • Leonidas Benetatos
    • 1
    Email author
  • George Vartholomatos
    • 2
  • Eleftheria Hatzimichael
    • 3
  1. 1.Blood Bank, Selefkeias 2Preveza General HospitalPrevezaGreece
  2. 2.Molecular Biology LaboratoryIoannina University HospitalIoanninaGreece
  3. 3.Department of HematologyIoannina University HospitalIoanninaGreece

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