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Cellular and Molecular Life Sciences

, Volume 71, Issue 18, pp 3553–3567 | Cite as

Wnt–Notch signalling crosstalk in development and disease

  • Giovanna M. Collu
  • Ana Hidalgo-Sastre
  • Keith BrennanEmail author
Review

Abstract

The Notch and Wnt pathways are two of only a handful of highly conserved signalling pathways that control cell-fate decisions during animal development (Pires-daSilva and Sommer in Nat Rev Genet 4: 39–49, 2003). These two pathways are required together to regulate many aspects of metazoan development, ranging from germ layer patterning in sea urchins (Peter and Davidson in Nature 474: 635–639, 2011) to the formation and patterning of the fly wing (Axelrod et al in Science 271:1826–1832, 1996; Micchelli et al in Development 124:1485–1495, 1997; Rulifson et al in Nature 384:72–74, 1996), the spacing of the ciliated cells in the epidermis of frog embryos (Collu et al in Development 139:4405–4415, 2012) and the maintenance and turnover of the skin, gut lining and mammary gland in mammals (Clayton et al in Nature 446:185–189, 2007; Clevers in Cell 154:274–284, 2013; Doupe et al in Dev Cell 18:317–323, 2010; Lim et al in Science 342:1226–1230, 2013; Lowell et al in Curr Biol 10:491–500, 2000; van et al in Nature 435:959–963, 2005; Yin et al in Nat Methods 11:106–112, 2013). In addition, many diseases, including several cancers, are caused by aberrant signalling through the two pathways (Bolós et al in Endocr Rev 28: 339–363, 2007; Clevers in Cell 127: 469–480, 2006). In this review, we will outline the two signalling pathways, describe the different points of interaction between them, and cover how these interactions influence development and disease.

Keywords

Notch Wnt Signalling crosstalk Development Disease 

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Copyright information

© Springer Basel 2014

Authors and Affiliations

  • Giovanna M. Collu
    • 1
    • 2
  • Ana Hidalgo-Sastre
    • 1
    • 3
  • Keith Brennan
    • 1
    Email author
  1. 1.Faculty of Life SciencesUniversity of ManchesterManchesterUK
  2. 2.Department of Developmental & Regenerative BiologyIcahn School of Medicine at Mount SinaiNew YorkUSA
  3. 3.II Medizinische Klinik, Klinikum rechts der IsarTechnische Universität MünchenMunichGermany

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