Cellular and Molecular Life Sciences

, Volume 71, Issue 4, pp 615–627

Fate choice of post-natal mesoderm progenitors: skeletal versus cardiac muscle plasticity

  • Domiziana Costamagna
  • Mattia Quattrocelli
  • Robin Duelen
  • Vardine Sahakyan
  • Ilaria Perini
  • Giacomo Palazzolo
  • Maurilio Sampaolesi


Regenerative medicine for skeletal and cardiac muscles still constitutes a fascinating and ambitious frontier. In this perspective, understanding the possibilities of intrinsic cell plasticity, present in post-natal muscles, is vital to define and improve novel therapeutic strategies for acute and chronic diseases. In addition, many somatic stem cells are now crossing the boundaries of basic/translational research to enter the first clinical trials. However, it is still an open question whether a lineage switch between skeletal and cardiac adult myogenesis is possible. Therefore, this review focuses on resident somatic stem cells of post-natal skeletal and cardiac muscles and their plastic potential toward the two lineages. Furthermore, examples of myogenic lineage switch in adult stem cells are also reported and discussed.


Skeletal muscle Cardiac muscle Resident stem cells Myogenic regeneration Muscular dystrophy Lineage switch 


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Copyright information

© Springer Basel 2013

Authors and Affiliations

  • Domiziana Costamagna
    • 1
  • Mattia Quattrocelli
    • 1
  • Robin Duelen
    • 1
  • Vardine Sahakyan
    • 1
  • Ilaria Perini
    • 1
  • Giacomo Palazzolo
    • 1
  • Maurilio Sampaolesi
    • 1
  1. 1.Translational Cardiomyology Lab, Department of Development and Regeneration, Stem Cell Institute Leuven, Embryo and Stem Cell BiologyKU LeuvenLeuvenBelgium

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