Cellular and Molecular Life Sciences

, Volume 70, Issue 23, pp 4431–4448 | Cite as

Positive and negative influence of the matrix architecture on antitumor immune surveillance

  • Elisa Peranzoni
  • Ana Rivas-Caicedo
  • Houcine Bougherara
  • Hélène Salmon
  • Emmanuel DonnadieuEmail author


The migration of T cells and access to tumor antigens is of utmost importance for the induction of protective anti-tumor immunity. Once having entered a malignant site, T cells encounter a complex environment composed of non-tumor cells along with the extracellular matrix (ECM). It is now well accepted that a deregulated ECM favors tumor progression and metastasis. Recent progress in imaging technologies has also highlighted the impact of the matrix architecture found in solid tumor on immune cells and especially T cells. In this review, we argue that the ability of T cells to mount an antitumor response is dependent on the matrix structure, more precisely on the balance between pro-migratory reticular fiber networks and unfavorable migration zones composed of dense and aligned ECM structures. Thus, the matrix architecture, that has long been considered to merely provide the structural framework of connective tissues, can play a key role in facilitating or suppressing the antitumor immune surveillance. A new challenge in cancer therapy will be to develop approaches aimed at altering the architecture of the tumor stroma, rendering it more permissive to antitumor T cells.


Tumor T cells Stroma Extracellular matrix Motility Imaging 





Extracellular matrix


Epithelial-mesenchymal transition


Fibroblastic reticular cells


Lysyl oxidase


Lymphoid tissue inducer




Second-harmonic generation


Secondary lymphoid organs


Tumor-associated collagen signature


Tumor-infiltrating lymphocytes


Tertiary lymphoid organs



We thank Nadège Bercovici and Alain Trautmann for critical reading of the manuscript. We are grateful to Diane Damotte and Marie-Aude Le Frère-Belda for providing the human specimens shown in Fig. 1. This work was supported in part by grants from the Ligue Nationale Contre le Cancer and the Institut National Contre le Cancer. Ana Rivas-Caicedo is supported by an Association pour la recherche sur le Cancer postdoctoral fellowship. Elisa Peranzoni is a recipient of the Fondazione Italiana per la Ricerca sul Cancro.


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Copyright information

© Springer Basel 2013

Authors and Affiliations

  • Elisa Peranzoni
    • 1
    • 2
    • 3
  • Ana Rivas-Caicedo
    • 4
  • Houcine Bougherara
    • 1
    • 2
    • 3
  • Hélène Salmon
    • 5
  • Emmanuel Donnadieu
    • 1
    • 2
    • 3
    • 6
    Email author
  1. 1.Inserm, U1016, Institut CochinParisFrance
  2. 2.Cnrs UMR8104ParisFrance
  3. 3.Université Paris DescartesSorbonne Paris CitéFrance
  4. 4.Alta Tecnología en Laboratorios SA de CVMexicoMexico
  5. 5.Department of Oncological SciencesMount Sinai School of MedicineNew YorkUSA
  6. 6.Département d’Immunologie et d’HématologieInstitut CochinParisFrance

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