Cellular and Molecular Life Sciences

, Volume 70, Issue 10, pp 1779–1792

Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells

  • Jean-Leon Thomas
  • Kasey Baker
  • Jinah Han
  • Charles Calvo
  • Harri Nurmi
  • Anne C. Eichmann
  • Kari Alitalo
Multi-author review

DOI: 10.1007/s00018-013-1312-6

Cite this article as:
Thomas, JL., Baker, K., Han, J. et al. Cell. Mol. Life Sci. (2013) 70: 1779. doi:10.1007/s00018-013-1312-6

Abstract

Notch cell interaction mechanism governs cell fate decisions in many different cell contexts throughout the lifetime of all Metazoan species. It links the fate of one cell to that of its neighbors through cell-to-cell contacts, and binding of Notch receptors expressed on one cell to their membrane bound ligands on an adjacent cell. Environmental cues, such as growth factors and extracellular matrix molecules, superimpose a dynamic regulation on this canonical Notch signaling pathway. In this review, we will focus on Notch signaling in the vertebrate vascular and nervous systems and examine its role in angiogenesis, neurogenesis, and neurovascular interactions. We will also highlight the molecular relationships of the Notch pathway with vascular endothelial growth factors (VEGFs) and their high-affinity tyrosine kinase VEGF receptors, key regulators of both angiogenesis and neurogenesis.

Keywords

Angiogenesis Neurogenesis Neurovascular interactions Notch VEGFs VEGFRs 

Copyright information

© Springer Basel 2013

Authors and Affiliations

  • Jean-Leon Thomas
    • 1
    • 3
    • 4
    • 5
  • Kasey Baker
    • 2
  • Jinah Han
    • 2
  • Charles Calvo
    • 3
    • 4
    • 5
  • Harri Nurmi
    • 6
  • Anne C. Eichmann
    • 2
    • 7
  • Kari Alitalo
    • 6
  1. 1.Department of NeurologyYale University School of MedicineNew HavenUSA
  2. 2.Department of CardiologyYale University School of MedicineNew HavenUSA
  3. 3.Université Pierre and Marie Curie–Paris 6, CRICMGroupe Hospitalier Pitié-SalpètrièreParisFrance
  4. 4.INSERM, UMRS 975Groupe Hospitalier Pitié-SalpètrièreParisFrance
  5. 5.APHPGroupe Hospitalier Pitié-SalpètrièreParisFrance
  6. 6.Wihuri Institute and Molecular Molecular/Cancer Biology Laboratory, Biomedicum Helsinki and Department of Pathology Haartman InstituteUniversity of HelsinkiHelsinkiFinland
  7. 7.CNRS/UMRCenter for Interdisciplinary Research in BiologyParisFrance

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