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Cellular and Molecular Life Sciences

, Volume 70, Issue 20, pp 3773–3789 | Cite as

Deciphering microRNA code in pain and inflammation: lessons from bladder pain syndrome

  • Ali Hashemi Gheinani
  • Fiona C. Burkhard
  • Katia MonastyrskayaEmail author
Review

Abstract

MicroRNAs (miRNAs), a novel class of molecules regulating gene expression, have been hailed as modulators of many biological processes and disease states. Recent studies demonstrated an important role of miRNAs in the processes of inflammation and cancer, however, there are little data implicating miRNAs in peripheral pain. Bladder pain syndrome/interstitial cystitis (BPS/IC) is a clinical syndrome of pelvic pain and urinary urgency/frequency in the absence of a specific cause. BPS is a chronic inflammatory condition that might share some of the pathogenetic mechanisms with its common co-morbidities inflammatory bowel disease (IBD), asthma and autoimmune diseases. Using miRNA profiling in BPS and the information about validated miRNA targets, we delineated the signaling pathways activated in this and other inflammatory pain disorders. This review projects the miRNA profiling and functional data originating from the research in bladder cancer and immune-mediated diseases on the BPS-specific miRNAs with the aim to gain new insight into the pathogenesis of this enigmatic disorder, and highlighting the common regulatory mechanisms of pain and inflammation.

Keywords

MicroRNA Bladder Pain Inflammation Gene expression Bladder cancer Inflammatory bowel disease 

Notes

Acknowledgments

We gratefully acknowledge the financial support of the Swiss National Science Foundation (SNF Grant 320030_135783/1 to K. Monastyrskaya).

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Copyright information

© Springer Basel 2013

Authors and Affiliations

  • Ali Hashemi Gheinani
    • 1
  • Fiona C. Burkhard
    • 2
  • Katia Monastyrskaya
    • 1
    Email author
  1. 1.Department of Clinical Research, Urology Research LaboratoryUniversity of BernBernSwitzerland
  2. 2.Department of UrologyUniversity HospitalBernSwitzerland

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