Cellular and Molecular Life Sciences

, Volume 70, Issue 15, pp 2623–2636 | Cite as

Heat stress response of male germ cells

Review

Abstract

The vast majority of mammalian testes are located outside the body cavity for proper thermoregulation. Heat has an adverse effect on mammalian spermatogenesis and eventually leads to sub- or infertility. Recent studies have provided insights into the molecular response of male germ cells to high temperatures. Here, we review the effects of heat on male germ cells and discuss the mechanisms underlying germ cell loss and impairment. We also discuss the role of translational control in male germ cells as a potential protective mechanism against heat-induced germ cell apoptosis.

Keywords

Hyperthermia Spermatogenesis Infertility Heat stress Germ cell apoptosis DNA damage Stress granules 

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© Springer Basel AG 2012

Authors and Affiliations

  1. 1.Department of Biological SciencesSeoul National UniversitySeoulKorea

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